| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Fluorine-containing compounds have increased their importance as pharmaceuticals and agrochemicals especially in recent years. We have focused our attention on difluorocarbene complexes that would realize highly efficient syntheses of organofluorine compounds with metal catalysts. We disclosed that nickel(II) and copper(I) complexes generated the corresponding difluorocarbene complexes and that selective syntheses of isomeric α,α- and β,β-difluorocyclopentanone derivatives were facilitated starting from common silyl dienol ethers. The structures that we successfully constructed in this project are ubiquitously found in biologically active compounds, which leads to development of pharmaceuticals and agrochemicals.
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