Catalytic Syntheses of Fluorine-Containing Compounds via Fluorine-Substituted Transition Metal Carbene Complexes
| Project/Area Number |
16K13943
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Organic chemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 触媒 / フッ素 / カルベン錯体 / ニッケル / 銅 / 医薬 / 農薬 / ビニリデン錯体 / フルオロアルケン / ピロール / シクロペンタノイド / 付加環化 / 位置異性体 / 有機化学 / 合成化学 / 触媒・化学プロセス / 遷移金属錯体 / 含フッ素有機化合物 |
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| Outline of Final Research Achievements |
Fluorine-containing compounds have increased their importance as pharmaceuticals and agrochemicals especially in recent years. We have focused our attention on difluorocarbene complexes that would realize highly efficient syntheses of organofluorine compounds with metal catalysts. We disclosed that nickel(II) and copper(I) complexes generated the corresponding difluorocarbene complexes and that selective syntheses of isomeric α,α- and β,β-difluorocyclopentanone derivatives were facilitated starting from common silyl dienol ethers. The structures that we successfully constructed in this project are ubiquitously found in biologically active compounds, which leads to development of pharmaceuticals and agrochemicals.
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Report
(3 results)
Research Products
(52 results)
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[Journal Article] Facile Synthesis of Polycyclic Aromatic Hydrocarbons: Bronsted Acid-Catalyzed Dehydrative Cycloaromatization of Carbonyl Compounds in 1,1,1,3,3,3- Hexafluoropropan-2-ol2017
Author(s)
Fujita, T.; Takahashi, I.; Hayashi, M.; Wang, J.; Fuchibe, K.; Ichikawa, J.
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Journal Title
European Journal of Organic Chemistry
Volume: 2
Issue: 2
Pages: 262-265
DOI
Related Report
Peer Reviewed
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