Development of Regioselective C-H Trifluoromethylation
Project/Area Number |
16K13946
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Organic chemistry
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Research Institution | Kyushu University |
Principal Investigator |
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | トリフルオロメチル化 / 位置選択的 / ヘテロ芳香族化合物 / Lewis酸-塩基相互作用 / Lewis酸 / 銅触媒 / トリフルオロメチルアニオン / ヘテロ芳香環 / 芳香環 / フッ素官能基 |
Outline of Final Research Achievements |
We succeeded in the development of the first 4-position-selective C-H trifluoromethylation of six-membered heteroaromatic compounds by electrophilically activating the six-membered heteroaromatic rings and sterically protecting the 2-position of the heteroaromatic rings.We developed copper-catalyzed 5-position-selective C-H trifluoromethylation of N-(8-quinolynyl)pivalamides. In addition, we succeeded in the inprovement of previously reported 2-position-selective C-H trifluoromethylation of six-membered heteroaromatic compounds. By using this reaction, a trifluoromethyl group can be introduced into the 2-position of quinoline derivatives in short reaction steps efficiently.
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Report
(3 results)
Research Products
(15 results)