| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We succeeded in the development of the first 4-position-selective C-H trifluoromethylation of six-membered heteroaromatic compounds by electrophilically activating the six-membered heteroaromatic rings and sterically protecting the 2-position of the heteroaromatic rings.We developed copper-catalyzed 5-position-selective C-H trifluoromethylation of N-(8-quinolynyl)pivalamides. In addition, we succeeded in the inprovement of previously reported 2-position-selective C-H trifluoromethylation of six-membered heteroaromatic compounds. By using this reaction, a trifluoromethyl group can be introduced into the 2-position of quinoline derivatives in short reaction steps efficiently.
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