Stereochemical Study on Chiral Silicon Radical and Its Application for Novel Asymmetric Synthesis
| Project/Area Number |
16K13955
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Organic chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IGAWA Kazunobu 九州大学, 先導物質化学研究所, 助教 (80401529)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 有機合成化学 / 不斉ケイ素化学 / ラジカル反応 / 不斉合成 |
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| Outline of Final Research Achievements |
To explore a chemistry of chiral silicon radical, we examined asymmetric synthesis of radical precursors and reactions. As result, we have developed highly stereoselective approach to chiral hydrosilanes based on, a) nucleophilic substitution reaction of alkoxysilane and organometallic reagent, and, b) asymmetric beta-elimination of silacyclopenteneoxide. And we accomplished stereoselective preparation of chiral silicon radicals from the hydrosilanes.
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Report
(3 results)
Research Products
(16 results)
