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Development of innovative molecular devices based on molecular inclusion reaction

Research Project

Project/Area Number 16K13961
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Inorganic chemistry
Research InstitutionNagoya University

Principal Investigator

Yamada Yasuyuki  名古屋大学, 物質科学国際研究センター, 准教授 (10385552)

Research Collaborator Itoh Ryosuke  
Ogino Sayaka  
Mihara Nozomi  
Nawate Katsuhiko  
Maeno Tomoaki  
Furukawa Ko  
Kato Tatsuhisa  
Akine Shigehisa  
Sugimoto Kunihisa  
Shimokawa Koya  
Igawa Kazunobu  
Tomooka Katsuhiko  
Tanaka Kentaro  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsポルフィリン / フタロシアニン / ロタキサン / 分子機械 / インターロック型分子組織 / 分子包接反応 / カテナン / 分子包接 / 分子デバイス
Outline of Final Research Achievements

We synthesized a multiply interlocked molecular assembly (M) with a novel topological structure in which a cofacial porphyrin dimer connected with four alkylammonium chains is quadruply interlocked by a phthalocyanine bearing four peripheral crown ethers. Since M has such a flexible structure that an alternative addition of an appropriate acid and a base resulted in its dynamic conformational change. It was demonstrated that M incorporates π-planer anions in its two isolated nanospaces in between a porphyrin and a phthalocyanine. It was also found that M showed unique molecular inclusion behavior in which a central phthalocyanine moves like a “slide door” to capture a guest molecule. This behavior is quite similar to the “induced fit” found in natural enzymes.

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は主に以下の2つである。(i)これまでにないトポロジーを有する多重インターロック型ポルフィリン・フタロシアニン分子組織を構築し、その構造変化特性を明らかにした点。(ii)この分子組織がその柔軟かつユニークな構造を利用して、天然の酵素の「induced fit」に類似した分子認識様式を示すことを明らかにした点。特に、この分子組織はinduced fit型の分子認識を示す初めての人工ホスト分子の合成例であり、その設計原理を明らかにした点でその学術的意義は大きいと言える。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Journal Article] Intramolecular Strong Electronic Coupling in a Discretely H-Aggregated Phthalocyanine Dimer Connected with a Rigid Linker2018

    • Author(s)
      Yamada, Y.; Nawate, K.; Maeno, T.; Tanaka, K.
    • Journal Title

      Chem. Commun.

      Volume: 54 Issue: 59 Pages: 8226-8228

    • DOI

      10.1039/c8cc04335c

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Programmable Arrangement of Metal Ions in a Cofacially Stacked Assembly of Porphyrinoids toward Molecular Tags2018

    • Author(s)
      Mihara Nozomi、Yamada Yasuyuki、Furukawa Ko、Kato Tatsuhisa、Tanaka Kentaro
    • Journal Title

      Dalton Transactions

      Volume: 47 Issue: 20 Pages: 7044-7049

    • DOI

      10.1039/c8dt01334a

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic Molecular Invasion into a Multiply Interlocked Catenane2017

    • Author(s)
      Yamada Yasuyuki、Itoh Ryohei、Ogino Sayaka、Kato Tatsuhisa、Tanaka Kentaro
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 56 Issue: 45 Pages: 14124-14129

    • DOI

      10.1002/anie.201708248

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Electronic Perturbation of Supramolecular Conjugates of Porphyrins and Phthalocyanines2017

    • Author(s)
      N. Mihara, Y. Yamada, S. Akine, K. Sugimoto, and K. Tanaka
    • Journal Title

      Chem. Commun.

      Volume: 53 Issue: 14 Pages: 2230-2232

    • DOI

      10.1039/c6cc09590a

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 超分子会合体形成反応を利用した窒素架橋鉄ポルフィリノイド二核錯体型エタン酸化触媒の活性化2018

    • Author(s)
      山田 泰之, 三原 のぞみ, 森田 健太郎, 高谷 光, 北河 康隆, 井川 和宣, 友岡 克彦, 田中 健太郎
    • Organizer
      第16回ホストーゲスト・超分子化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Enhancement of Catalytic Ethane Oxidation Activity of μ-Nitrido-Bridged Iron Porphyrinoid Dimer by Supramolecular Complexation2018

    • Author(s)
      Yasuyuki Yamada, Kentaro Tanaka
    • Organizer
      43rd International Conference on Coordination Chemistry (ICCC2018)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Discrete Cofacial Assemblies of Porphyrin and Phthalocyanine Connected through Flexible Linkages2017

    • Author(s)
      Yasuyuki Yamada
    • Organizer
      SPIRITS international symposium 3
    • Place of Presentation
      Kyoto University
    • Year and Date
      2017-02-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] ダイナミックな構造変化が可能な 多重カテナン型ポルフィリン・フタロシアニン会合体の構築2017

    • Author(s)
      山田泰之・伊藤涼平・荻野沙也佳・加藤立久・田中健太郎
    • Organizer
      第66回高分子討論会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] A Multiply Interlocked Assembly of Porphyrin and Phthalocyanine2016

    • Author(s)
      Yasuyuki Yamada
    • Organizer
      ISPAC2016
    • Place of Presentation
      Borneo Convention Centre Kuching, Malaysia
    • Year and Date
      2016-08-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 多重カテナン形成とインターカレーションによる ポルフィリン・フタロシアニン分子組織の構築2016

    • Author(s)
      山田 泰之、伊藤 涼平、荻野 沙也佳、加藤 立久、田中 健太郎
    • Organizer
      第14回ホストゲスト化学シンポジウム
    • Place of Presentation
      高知城ホール
    • Year and Date
      2016-06-04
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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