Development of Mononucelar Copper-oxyl Radical Species
| Project/Area Number |
16K13963
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Inorganic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
Itoh Shinobu 大阪大学, 工学研究科, 教授 (30184659)
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| Research Collaborator |
MORIMOTO Yuma
Sugimoto Hideki
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 単核銅錯体 / 活性酸素錯体 / オキシラジカル錯体 / 酸化反応 / 金属酵素 / 錯体触媒 / 反応機構 / 酸化活性種 / 銅含有酸化酵素 |
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| Outline of Final Research Achievements |
The mononuclear copper(II)-superoxide complex has been involved as a key reactive intermediate in a variety of oxidation reactions catalyzed by copper-containing metalloenzymes and several types of copper model complexes. However, little was known about the physicochemical properties and reactivity. In this study, the reactions of copper complexes supported by our functional ligands and peroxides have been investigated in detail to demonstrate possible contribution of such a mononuclear copper(II)-superoxide species in the oxidation reactions.
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| Academic Significance and Societal Importance of the Research Achievements |
単核銅(II)-オキシラジカル種は、銅含有金属酵素や各種銅錯体が触媒する種々の酸化反応に含まれる重要な酸化活性種である。しかし、その詳細な構造や物性、および反応性に関する情報は全くなく、それらの解明は、生物無機化学や触媒化学の分野における重要な研究課題となっている。本研究で得られた成果は、この様な銅-活性酸素錯体の反応性に関して重要な情報を提供するものであり、生体反応や各種酸化反応の機構解明につながるものとして学術的意義は大きい。また、新しい錯体触媒の開発に対しても有用な指針を提供するものであり、錯体化学や触媒化学の発展に大きく寄与するものである。
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Tetrahedral Copper(II) Complexes with a Labile Coordination Site Supported by a tris-Tetramethylguanidinato Ligand2017
Author(s)
Ikuma Shimizu, Yuma Morimoto, Dieter Faltermeier, Marion Kerscher, Sayantan Paria, Tsukasa Abe, Hideki Sugimoto, Nobutaka Fujieda, Kaori Asano, Takeyuki Suzuki, Peter Comba,* and Shinobu Itoh*
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Journal Title
Inorg. Chem.
Volume: 56
Issue: 16
Pages: 9634-9645
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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