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Fabrication of Sensors for Bio-environments by Fluorescence Nanosheets and Development for Devices

Research Project

Project/Area Number 16K14009
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Polymer chemistry
Research InstitutionWaseda University

Principal Investigator

Takeoka Shinji  早稲田大学, 理工学術院, 教授 (20222094)

Co-Investigator(Renkei-kenkyūsha) FUJIE Toshinori  早稲田大学, 高等研究所, 准教授 (70538735)
Research Collaborator SATO Hirotaka  Nanyang Technological University, School of Mechanical & Aerospace Engineering, College of Engineering, Associate Professor
SOMEYA Daichi  早稲田大学, 大学院先進理工学研究科
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords高分子薄膜 / ナノシート / レシオ型計測 / 蛍光センサー / pHセンサー / 酸素センサー / 温度センサー / デバイス / 薄膜型蛍光センサ / 酸素センサ / 温度センサ / pHセンサ / 環境モニタリング / 温湿度 / 酸素濃度
Outline of Final Research Achievements

The temperature, humidity, oxygen density and pH are controlled comfortably for creatures in the living environment. However, we need expensive systems to keep this due to the complexity by which more than one factors should be measured for more than one points in real time. In this study, the reporter aimed to develop the nanosheet-type fluorescence sensors, adhesive on the target surface, and a device for practical measurements. The temperature and oxygen sensors were successfully prepared by introducing fluorescence molecules sensing temperature and oxygen into polymer nanosheets and combining with a standard fluorescence nanosheet insensitive to those factors. The reporter designed a pH sensor by considering time resolution influenced by membrane thickness. Then, the reporter successfully prepared a nanosheet-type fluorescence pH sensor by synthesizing fluorescence-conjugated polymers, using a layer-by-layer method, and combining with the standard fluorescence nanosheet.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (14 results)

All 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 6 results,  Invited: 4 results) Remarks (2 results)

  • [Int'l Joint Research] NTU(シンガポール)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] NTU(シンガポール)

    • Related Report
      2016 Research-status Report
  • [Journal Article] 高分子ナノ薄膜とバイオ・エレクトロニクスの融合2017

    • Author(s)
      藤枝 俊宣, 武岡 真司
    • Journal Title

      化学と工業

      Volume: 70(6) Pages: 494-496

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glue-Free Stacked Luminescent Nanosheets Enable High-Resolution Ratiometric Temperature Mapping in Living Small Animals2016

    • Author(s)
      Takuya Miyagawa, Toshinori Fujie, Ferdinandus, Tat Thang Vo Doan, Hirotaka Sato, and Shinji Takeoka
    • Journal Title

      ACS Appl. Mater. Interfaces

      Volume: 8 Issue: 49 Pages: 33377-33385

    • DOI

      10.1021/acsami.6b06075

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Development of Nanomaterials Functionalized by 3D Collaboration2018

    • Author(s)
      Shinji Takeoka
    • Organizer
      4th Core-to-Core International Symposium "3D Lab-Exchange Program"
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] pHマッピングを可能とするナノシート型蛍光センサーの構築2017

    • Author(s)
      染谷大地
    • Organizer
      日本化学会第97回春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Luminescent Nanosheets for Ratiometric Temperature Mapping2017

    • Author(s)
      Shinji Takeoka
    • Organizer
      European Advanced Materials Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Ratiometric Temperature Mapping of Living Tissues Using Ultra-Conformable Polymer Nanosheets Loading Thermo-Sensitive Dyes2017

    • Author(s)
      Toshinori Fujie
    • Organizer
      2017 MRS Fall Meeting & Exhibit
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Thermo-sensitive dye laden polymer nanosheets for ratiometric temperature mapping of living muscle tissues.2017

    • Author(s)
      Toshinori Fujie
    • Organizer
      254th American Chemical Society National Meeting & Exposition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Luminescent Temperature Imaging by Polymeric Nanosheets2016

    • Author(s)
      Shinji Takeoka
    • Organizer
      The 11th SPSJ International Polymer Conference
    • Place of Presentation
      Fukuoka
    • Year and Date
      2016-12-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Ratiometric fluorescent temperature sensing for mitochondria and muscle2016

    • Author(s)
      Shinji Takeoka
    • Organizer
      JSPS Core-to-Core Program, 3D Lab Exchange Symposium
    • Place of Presentation
      Pisa
    • Year and Date
      2016-09-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 温度・酸素感受性高分子ナノ材料によるバイオイメージング2016

    • Author(s)
      武岡真司
    • Organizer
      第65回高分子討論会
    • Place of Presentation
      神奈川大学
    • Year and Date
      2016-09-15
    • Related Report
      2016 Research-status Report
  • [Remarks] Takeoka Lab

    • URL

      http://www.takeoka.biomed.sci.waseda.ac.jp/pages/index/

    • Related Report
      2017 Annual Research Report
  • [Remarks] Takeoka Lab

    • URL

      http://www.takeoka.biomed.sci.waseda.ac.jp/pages/index/

    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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