| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Natural nucleic acids can form a triplex and a quadruplex by forming hydrogen bonds at both sides of purine bases. In this study, we synthesized novel artificial nucleic acids bearing novel nucleobases, which have hydrogen bonding sites at both sides. And we found that a hexaplex was successfully formed by these nucleic acids. The hexaplex was stabilized in the presence of divalent cations and low pH, indicating the potential of the hexaplex as pH and metal ion sensors. Molecular modelling calculation indicated that the hexaplex has a very unique structure with a pore at its center. It could be applied as novel supramolecular motifs and ion channels.
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