Development of plasmonic biosensor for the detection of nucleic acid
| Project/Area Number |
16K14039
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Bio-related chemistry
|
|---|
| Research Institution | University of Hyogo |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
高田 忠雄 兵庫県立大学, 工学研究科, 准教授 (60511699)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | DNA / プラズモン / 核酸 / バイオセンサー / 電気化学 / 光電流 / 金ナノ粒子 / クロモフォア / 近接場光 / 核酸検出 / 光電子移動 / センサー |
|---|
| Outline of Final Research Achievements |
A monolayer of gold nanoparticles (AuNP) on an electrode was constructed by using DNA hybridization between oligonucleotides on the AuNP and on the electrode. The electrochemical response of the AuNP-modified electrode was observed by electrochemical measurements after the modification of the surface with perylenediimide dyes used as photoactive molecules. Light irradiation on the surface without the AuNP showed weak photocurrent, while strong photocurrent generation was observed when the electrode was covered with the AuNP. This enhancement was explained by an increase in the excitation efficiency of the PDI molecules bound to the DNA connecting the electrode and the AuNP.
|
Report
(3 results)
Research Products
(3 results)
