Determination of potential health risks of bioactive chemicals in reclaimed water
| Project/Area Number |
16K14051
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Green/Environmental chemistry
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
Kim Sung Bae 国立研究開発法人産業技術総合研究所, 環境管理研究部門, 主任研究員 (60470043)
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| Research Collaborator |
FUJII Rika 国立研究開発法人産業技術総合研究所, 環境管理研究部門
WU Qian-Yuan 清華大学, 深圳研究生院
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 再生水 / 生物発光 / 発光プローブ / イメージング / 化学物質 / ホルモン様活性 / 毒性 / 生理活性 / 毒性評価 / 人工化学物質 / 生理活性物質 / バイオアッセイ / 一分子型生物発光プローブ / 可視化 / 環境分析 / 有害化学物質 / 分析科学 / バイオテクノロジー |
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| Outline of Final Research Achievements |
During the period, the researchers conducted a series of studies on colorimetrical technology for determining unexpected, potential risk factors of man-made chemicals in reclaimed water. First, divalent cations in reclaimed water were colorimetrically examined with cation-sensitive artificial luciferases (ALucs), which was originally developed the researchers. Further, we determined (i) the male and female sex hormone-like activities and the antagonistic effects, and (ii) teratogenicity of man-made chemicals in reclaimed water. The study revealed that some chemicals have a synergetic effect by combining with other chemicals, although they are poor in the antagonistic activity to female sex hormones. A new luminescent probe was also developed for determining immunotoxicity of chemicals in reclaimed water. We published 8 science journals and conducted 6 presentations in academic society meetings.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Azide- and Dye-Conjugated Coelenterazine Analogues for a Multiplex Molecular Imaging Platform2018
Author(s)
Ryo Nishihara, Emi Hoshino, Yoshiki Kakudate, Satoshi Kishigami, Naoko Iwasawa, Shin-ichi Sasaki, Takahiro Nakajima, Moritoshi Sato, Shigeru Nishiyama, Daniel Citterio, Koji Suzuki, Sung Bae Kim
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Journal Title
Bioconjugate Chemistry (ACS)
Volume: 印刷中
Issue: 6
Pages: 1922-1931
DOI
Related Report
Peer Reviewed
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