Development of in vivo measurement of drug permeation and enhancement of transdermal drug delivery

• Project/Area Number: 16K14150
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Fluid engineering
• Research Institution: Tohoku University
• Principal Investigator: Kikuchi Kenji 東北大学, 工学研究科, 准教授 (00553801)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 経皮吸収促進 / 薬剤浸透 / in vivo計測 / 二光子顕微鏡 / 機械的刺激 / 工学 / 機械工学 / 流体工学 / バイオ流体力学

Outline of Final Research Achievements

To control a drug permeation from the skin surface, a three dimensional skin structure and precise drug permeation measurements are needed. We measured non-invasively the three dimensional skin structure by using a two photon microscopy and the drug permeation through the skin surface by using a confocal microscopy. As our results, the qualitative measurements of the strain of skin surface and the amount of permeated drug through the skin were succeeded. We found the mechanism of drug permeation through the skin surface with the skin extension.

Research Products

• [Presentation] 生体流動の可視化と生体ポンプの特性評価 (2018)
  • Author(s): 菊地謙次
  • Organizer: 第38回エアロ・アクアバイオメカニズム学会
  • Invited
• [Presentation] 機械的刺激による経皮吸収促進 (2017)
  • Author(s): 重田峻輔, 菊地謙次, 沼山恵子, 石川拓司
  • Organizer: 日本機械学会 第29回バイオエンジニアリング講演会
  • Place of Presentation: ウインクあいち （愛知県名古屋市）
  • Year and Date: 2017-01-19
• [Presentation] 伸展刺激による皮膚構造変化と薬剤浸透 (2017)
  • Author(s): 菅原尚, 重田峻輔, 菊地謙次, 沼山恵子, 石川拓司
  • Organizer: 日本機械学会 第29回バイオエンジニアリング講演会
  • Place of Presentation: ウインクあいち （愛知県名古屋市）
  • Year and Date: 2017-01-19
• [Presentation] TRANSDERMAL DRUG DELIVERY ENHANCEMENT BY UNIDIRECTIONAL SKIN EXTENSION (2017)
  • Author(s): Sho Sugawara, Kenji Kikuchi, Shunsuke Shigeta, Keiko Numayama-Tsuruta, Takuji Ishikawa
  • Organizer: The 26th Congress of the International Society of Biomechanics (ISB 2017)
  • Int'l Joint Research
• [Presentation] 伸展刺激による薬剤経皮吸収 (2017)
  • Author(s): 菅原尚, 菊地謙次, 沼山恵子, 石川拓司
  • Organizer: 日本機械学会第28回バイオフロンティア講演会
• [Presentation] 生物における流れの可視化とバイオイメージング (2017)
  • Author(s): 菊地謙次
  • Organizer: フロンティアバイオイメージング研究会
  • Invited
• [Presentation] MEASURMENT OF DRUG PERMEATION IN THE SKIN BY A TWO PHOTON MICROSCOPY (2016)
  • Author(s): Shunsuke Shigeta, Kenji Kikuchi, Keiko Numayama, Takuji Ishikawa
  • Organizer: 22nd Congress of the European Society of Biomechanics (ESB2016)
  • Place of Presentation: Lyon (France)
  • Year and Date: 2016-07-11
  • Int'l Joint Research