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3D Cell Structure Utilizing Micro 3D Printer and Cell Sheet

Research Project

Project/Area Number 16K14203
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionWaseda University

Principal Investigator

Umezu Shinjiro  早稲田大学, 理工学術院, 准教授 (70373032)

Co-Investigator(Kenkyū-buntansha) 坂口 勝久  早稲田大学, 理工学術院, 主任研究員(研究院准教授) (70468867)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords細動脈 / マイクロバイオ3Dプリンタ / 細胞シート / 三次元状細胞 / バイオエンジニアリング / セルシート / チタン細線 / 人工血管 / 3次元状細胞組織 / バイオプリント
Outline of Final Research Achievements

Recently, 3D cell structures are fabricated utilizing many kinds of biofabrication technologies. Cells those are located inside of the 3D structure get nutrition via capillary blood vessels. However, since the capillary is narrow, amount of nutrition is limited. In this study we fabricated cell structures those have arterioles inside.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (16 results)

All 2018 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Simple action potential measurement of cardiac cell sheet utilizing electronic sheet2018

    • Author(s)
      Ohya Takashi、Nakazono Kazuki、Kikuchi Tetsutaro、Sasaki Daisuke、Sakaguchi Katsuhisa、Shimizu Tatsuya、Fukuda Kenjiro、Someya Takao、Umezu Shinjiro
    • Journal Title

      Artificial Life and Robotics

      Volume: in printing Issue: 3 Pages: 321-327

    • DOI

      10.1007/s10015-018-0429-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Fundamental characteristics of printed gelatin utilizing micro 3D printer2017

    • Author(s)
      Tanaka Ryu-ichiro、Sakaguchi Katsuhisa、Umezu Shinjiro
    • Journal Title

      Artificial Life and Robotics

      Volume: 22 Issue: 3 Pages: 316-320

    • DOI

      10.1007/s10015-016-0348-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of micro-alginate gel tubes utilizing micro-gelatin fibers2017

    • Author(s)
      Sakaguchi Katsuhisa、Arai Takafumi、Shimizu Tatsuya、Umezu Shinjiro
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Issue: 5S2 Pages: 05EB06-05EB06

    • DOI

      10.7567/jjap.56.05eb06

    • NAID

      210000147784

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fabrication of three-dimensional tissue with vascular structure using cell sheet engineering and microtitanium wire2017

    • Author(s)
      秋元 渓、坂口 勝久、清水 達也、梅津 信二郎
    • Journal Title

      The Proceedings of Conference of Kanto Branch

      Volume: 2017.23 Issue: 0 Pages: 1313

    • DOI

      10.1299/jsmekanto.2017.23.1313

    • NAID

      130007077523

    • ISSN
      2424-2691
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Fabrication of micro-gelatin fiber utilizing coacervation method2017

    • Author(s)
      Takafumi AraiRyuichiro TanakaKatsuhisa SakaguchiShinjiro Umezu
    • Journal Title

      Artificial Life and Robotics

      Volume: 22 Issue: 2 Pages: 1-6

    • DOI

      10.1007/s10015-016-0344-z

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] アルギン酸ゲル作製方法の創成2018

    • Author(s)
      松本夏輝,田中龍一郎,梅津信二郎
    • Organizer
      IIP2018 情報・知能・精密機器部門(IIP部門)講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 超音波振動を用いたアルギン酸ゲル構造物の断面形状コントロール2018

    • Author(s)
      松本夏輝,田中龍一郎,梅津信二郎
    • Organizer
      関東学生会第57回学生員卒業研究発表講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マイクロ放電加工によるゼラチンゲルの複雑形状加工2018

    • Author(s)
      田村隆行,田中龍一郎,梅津信二郎
    • Organizer
      IIP2018 情報・知能・精密機器部門(IIP部門)講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ゼラチンゲルのマイクロ放電加工における加工形状の調査2017

    • Author(s)
      田村隆行,田中龍一郎,梅津信二郎
    • Organizer
      日本機械学会第1回機械材料・材料加工部門 若手ポスターシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] マイクロチタン線を用いた3次元状生体組織内への血管様構造の作製2017

    • Author(s)
      秋元渓,坂口勝久,清水達也, 梅津信二郎
    • Organizer
      日本材料学会関東支部 学生研究交流会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マイクロバイオ3Dプリンタを用いたバイオマテリアルゲルパターニング技術の開発2017

    • Author(s)
      田中龍一郎,坂口勝久,清水達也,梅津信二郎
    • Organizer
      第56回日本生体医工学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 細胞シート工学とマイクロチタンファイバーを用いた血管様構造を有する立体組織の構築2017

    • Author(s)
      秋元渓,新井隆史,坂口勝久,清水達也,梅津信二郎
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      宮城
    • Related Report
      2016 Research-status Report
  • [Presentation] マイクロチタン線を用いた細胞シート間における人工細動脈の作製2017

    • Author(s)
      秋元渓
    • Organizer
      第六回サイエンス・インカレ
    • Place of Presentation
      つくば
    • Related Report
      2016 Research-status Report
  • [Presentation] Fabrication of Soft Tissue Structure Utilizing Biofabrications and Investigation of its Bioelectric Potential2016

    • Author(s)
      Shinjiro Umezu, Takafumi Arai, Ryu-ichiro Tanaka, Takashi Ohya, Kei Akimoto, Katsuhisa Sakaguchi, Tatsuya Shimizu
    • Organizer
      Proc. Japanese American Frontiers of Science Symposium (JAFoS)
    • Place of Presentation
      Irvine, CA, USA
    • Year and Date
      2016-12-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Biomaterial Printing Utilizing Micro 3D Printer2016

    • Author(s)
      Ryu-ichiro Tanaka, Katsuhisa Sakaguchi, Tatsuya Shimizu, Shinjiro Umezu
    • Organizer
      CEMS Topical Meeting on Soft Robotics 2016
    • Place of Presentation
      Saitama, JAPAN
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] バイオマテリアルをコートしたチタン細線における細胞接着・成長特性2016

    • Author(s)
      秋元渓,坂口勝久,清水達也,梅津信二郎
    • Organizer
      第24回機械材料・材料加工技術講演会
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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