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Development of cell-integrated micro-photonic device

Research Project

Project/Area Number 16K14256
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Electron device/Electronic equipment
Research InstitutionNara Institute of Science and Technology

Principal Investigator

Ohta Jun  奈良先端科学技術大学院大学, 物質創成科学研究科, 教授 (80304161)

Co-Investigator(Renkei-kenkyūsha) TOKUDA Takashi  奈良先端科学技術大学院大学, 物質創成科学研究科, 准教授 (50314539)
SASAGWA Kiyotaka  奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (50392725)
NODA Toshihiko  奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (20464159)
TAKEHARA Hiroaki  奈良先端科学技術大学院大学, 研究推進機構, 特任助教 (60723088)
Project Period (FY) 2016-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords集積回路 / 細胞 / イメージセンサ / 蛍光 / フォトニックデバイス / 細胞センサ / LSI / バイオデバイス
Outline of Final Research Achievements

We have succeeded to culture GFP expressed HeLa cells on our micro-photonic device. An adhesive layer has been developed for this purpose. The absorption filter to detect green fluorescence from GFP and block blue light from an excitation light source have already been developed in our lab and can be applied to this experiment. The whole device is put into a PBS solution.
Next, we dropped a histamine solution onto the device. We have successfully demonstrated to obtain fluorescent image from the cells when a histamine solution is dropped. This clearly shows our device can be used as a cell-sensor to detect a chemical substance through fluorescence.

Report

(2 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (14 results)

All 2017 2016

All Presentation (14 results) (of which Int'l Joint Research: 7 results,  Invited: 11 results)

  • [Presentation] CMOS イメージセンサを用いた培養細胞のレンズレスオンチップ蛍光計測システム2017

    • Author(s)
      中元 健太, 大澤 和嵩, 春田 牧人, 野田 俊彦, 笹川 清隆, 徳田 崇, 太田 淳
    • Organizer
      第64回応用物理学会春季学術講演会
    • Place of Presentation
      パシフィコ横浜 神川県 横浜市
    • Year and Date
      2017-03-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Fabrication of a Prototype Dual Filter CMOS Image Sensor for FRET Imaging2017

    • Author(s)
      Hee Wan Shen,Haruta Makito,Noda Toshihiko,Sasagawa Kiyotaka,Tokuda Takashi,Ohta Jun
    • Organizer
      第64回応用物理学会春季学術講演会
    • Place of Presentation
      パシフィコ横浜 神川県 横浜市
    • Year and Date
      2017-03-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生体内埋植 CMOS デバイスを用いた生体機能の光による計測と操作2017

    • Author(s)
      太田 淳
    • Organizer
      日本学術振興会先端ナノデバイス・材料テクノロジー第151委員会
    • Place of Presentation
      LiSE 川崎生命科学・環境研究センター 神奈川県川崎市
    • Year and Date
      2017-03-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Implantable optoelectronic devices for controlling and measuring biological functions2017

    • Author(s)
      Jun Ohta
    • Organizer
      The 8th MEI3 Center International Symposium
    • Place of Presentation
      "Center of Medical Innovation and Translational Research Building, Suita, Osaka
    • Year and Date
      2017-03-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] An implantable imaging device for observing the recovery process from cerebrovascular disease in small animal brains2016

    • Author(s)
      Makito Haruta, Yoshinori Sunaga, Takahiro Yamaguchi, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
    • Organizer
      2016 GLOBAL RESEARCH EFFORTS ON ENERGY AND NANOMATERIALS
    • Place of Presentation
      GIS TAIPEI TECH Convention Center,Taiwan
    • Year and Date
      2016-12-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A portable cell imaging system with dual imaging functionality2016

    • Author(s)
      Makito Haruta, Anek Wuthayavanich, Kazutaka Osawa, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
    • Organizer
      5th International Conference on BioSensors, BioElectronics, BioMedical Devices, BioMEMS/NEMS & Applications 2016 (Bio4Apps2016)
    • Place of Presentation
      Griffith University, QLD, Australia
    • Year and Date
      2016-12-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 光電子デバイス技術による生体体機能の計測と操作2016

    • Author(s)
      太田 淳
    • Organizer
      計測自動制御学会  ライフエンジニアリング部門シンポジウム2016
    • Place of Presentation
      大阪国際交流センター 大阪府大阪市
    • Year and Date
      2016-11-04
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Optical-based Technologies for Brain Imaging and Manipulation2016

    • Author(s)
      Jun Ohta
    • Organizer
      The 2016 IEEE International Conference on Systems, Man, and Cybernetics (SMC 2016)
    • Place of Presentation
      Hotel Intercontinental Budapest, Budapest, Hungary
    • Year and Date
      2016-10-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] バイオ医療分野における半導体デバイスの役割と今後の展開2016

    • Author(s)
      太田 淳
    • Organizer
      DAシンポジウム2016
    • Place of Presentation
      山代温泉 ゆのくに天祥 石川県加賀市
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 細胞外因子に対する細胞応答のオンチップ蛍光計測2016

    • Author(s)
      大澤 和嵩,竹原 宏明,野田 俊彦,笹川 清隆,徳田 崇,太田 淳
    • Organizer
      第77回応用物理学会秋季学術講演会
    • Place of Presentation
      朱鷺メッセ 新潟県新潟市
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 埋植型光電子デバイスのバイオ医療への応用2016

    • Author(s)
      太田 淳
    • Organizer
      第77回応用物理学会秋季学術講演会
    • Place of Presentation
      朱鷺メッセ 新潟県新潟市
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] CMOS-Based Opto-Electronic Neural Interface Devices for Optogenetics2016

    • Author(s)
      Tokuda Takashi,Noguchi Satoki,Iwasaki Satoru,Takehara Hiroaki,Noda Toshihiko,Sasagawa Kiyotaka, Ohta Jun
    • Organizer
      The 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’16)
    • Place of Presentation
      Walt Disney World Resort, Orlando, FL, USA
    • Year and Date
      2016-08-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Micro-Optoelecronic Devices for Biomedical Applications2016

    • Author(s)
      Jun Ohta
    • Organizer
      2016 International Conference on Optical MEMS and Nanophotonics
    • Place of Presentation
      National University of Singapore, Singapore, Singapore
    • Year and Date
      2016-08-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Imaging Technology for Implantable Biomedical Applications2016

    • Author(s)
      Jun Ohta
    • Organizer
      International Symposium on Biomedical Engineering 2016
    • Place of Presentation
      Margo Hotel, Depok Java, Indonesia
    • Year and Date
      2016-05-30
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2018-03-22  

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