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A study on correlation between red blood cell aggregation measured by ultrasound scattering property due to blood flow cessation and diseases

Research Project

Project/Area Number 16K14272
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Measurement engineering
Research InstitutionTohoku University

Principal Investigator

Kanai Hiroshi  東北大学, 工学研究科, 教授 (10185895)

Co-Investigator(Kenkyū-buntansha) 瀧 宏文  東北大学, 医工学研究科, 非常勤講師 (40467460)
石垣 泰  岩手医科大学, 医学部, 教授 (50375002)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords超音波後方散乱特性 / 赤血球凝集度 / 糖尿病 / 血液性状 / 血糖値 / 医用超音波 / 高周波超音波 / 手背静脈 / 赤血球凝集 / 超音波後方錯乱 / 静脈血 / 非侵襲定量計測 / レイリ-散乱 / 高血糖状態 / 血糖値測定 / レイリー散乱 / CRP(C反応性たんぱく)血液検査 / ヘモグロビンA1c / 超音波後方散乱
Outline of Final Research Achievements

In the present study, we evaluated the degree of Red Blood Cell (RBC) aggregation at a low shear rate robustly by introducing new two parameters determined from changes in the scattering power spectrum of the echoes from the intravascular lumen before and after cessation of blood flow. We also considered the clinical significance of these parameters and the change in sizes estimated in the previous method by comparing them with the blood glucose level obtained just before the ultrasonic measurements. We applied the measurements on one healthy subject and 11 diabetic patients. The correlation was obtained between one of the proposed parameters and the blood glucose level. However, the p value was not so high and one of the reasons for the decline of the correlation will be that some factors other than blood glucose also affect the RBC aggregation. Thus, the proposed method has a potential in clinical applications by figuring out the various factors affecting RBC aggregation.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (24 results)

All 2017 2016

All Journal Article (17 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 17 results,  Open Access: 10 results,  Acknowledgement Compliant: 4 results) Presentation (7 results)

  • [Journal Article] A method for the design of ultrasonic devices for scanning acoustic microscopy using impulsive signals2017

    • Author(s)
      Mototaka Arakawa, Hiroshi Kanai, Kazuo Ishikawa, Ryo Nagaoka, Kazuto Kobayashi, and Yoshifumi Saijo
    • Journal Title

      Ultrasonics

      Volume: 84 Pages: 172-179

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attempt at standardization of bone quantitative ultrasound in Japan2017

    • Author(s)
      Takahiko Otani, Masao Fukunaga, Kosei Yho, Takami Miki, Kaoru Yamazaki, Hideaki Kishimoto, Mami Matsukawa, Nobuyuki Endoh, Hiroyuki Hachiya, Hiroshi Kanai, Saeko Fujiwara, and Yoshinori Nagai
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: 45 Pages: 3-13

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the heart wall and chamber based on temporal change of ultrasonic scatterer distribution2017

    • Author(s)
      Kohei Takahashi, Hirofumi Taki, and Hiroshi Kanai
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56

    • NAID

      210000148071

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultrasound imaging of propagation of myocardial contraction for non-invasive identification of myocardial ischemia2017

    • Author(s)
      Yuya Matsuno, Hirofumi Taki, Hiroaki Yamamoto, Michinori Hirano, Susumu Morosawa, Hiroaki Shimokawa, and Hiroshi Kanai
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56

    • NAID

      210000148067

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of synchronized change in ultrasonic integrated backscatter across human heart wall2017

    • Author(s)
      Yumi Tobinai, Hirofumi Taki, and Hiroshi Kanai
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56

    • NAID

      210000148066

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging of human vertebral surface using ultrasound RF data received at each element of probe for thoracic anesthesia2017

    • Author(s)
      Kazuki Takahashi, Hirofumi Taki, Eiko Onishi, Masanori Yamauchi, and Hiroshi Kanai
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56

    • NAID

      210000148063

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Near Real-time Measurement of Myocardial Contraction and Relaxation Based on High-frame-rate Ultrasound with a Graphical Processing Unit System2017

    • Author(s)
      Takuma Asai, Hirofumi Taki, Hiroshi Kanai
    • Journal Title

      IEEJ Transactions on Electronics, Information and Systems

      Volume: 137 Pages: 573-578

    • NAID

      130005530157

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Near Real-time Measurement of Myocardial Contraction and Relaxation Based on High-frame-rate Ultrasound with a Graphical Processing Unit System,2017

    • Author(s)
      Takuma Asai, Hirofumi Taki, Hiroshi Kanai
    • Journal Title

      IEEJ Transactions on Electronics, Information and Systems

      Volume: 137 Pages: 573-578

    • NAID

      130005530157

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deformability of the pulsating left ventricular wall: A new aspect elucidated by high resolution ultrasonic methods,2016

    • Author(s)
      Motonao Tanaka, Tsuguya Sakamoto, Shigeo Sugawara, Yoshiaki Katahira, Kaoru Hasegawa, Hiroyuki Nakajima, Takafumi Kurokawa, Hiroshi Kanai, Hideyuki Hasegawa
    • Journal Title

      Journal of Cardiology

      Volume: 印刷中 Issue: 2 Pages: 462-470

    • DOI

      10.1016/j.jjcc.2016.02.009

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corticosteroids Mediate Heart Failure-Induced Depression through Reduced σ1-Receptor Expression.2016

    • Author(s)
      Shinoda Y, Tagashira H, Bhuiyan MS, Hasegawa H, Kanai H, Zhang C, Han F, Fukunaga K.
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 10 Pages: 1-19

    • DOI

      10.1371/journal.pone.0163992

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Noninvasive early detection of anthracycline-induced cardiotoxicity in patients with hematologic malignancies using the phased tracking method2016

    • Author(s)
      Yoshiko Saito, Ikuko Susukida, Yoshiro Uzuka, Hiroshi Kanai
    • Journal Title

      Cancer Medicine

      Volume: 5 Issue: 9 Pages: 2276-2285

    • DOI

      10.1002/cam4.813

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis and methods to test classification of normal and pathological heart sound signals2016

    • Author(s)
      Rimuljo Hendradi, Achmad Arifin, Hiro Shida, Suhendar Gunawan, Mauridhi Hery Purnomo, Hideyuki Hasegawa, Hiroshi Kanai
    • Journal Title

      Journal of Theoretical and Applied Information Technology

      Volume: 90 Pages: 222-236

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Haloperidol aggravates transverse aortic constriction-induced heart failure via mitochondrial dysfunction2016

    • Author(s)
      Yasuharu Shinoda, Hideaki Tagashira, Md Shenuarin Bhuiyan, Hideyuki Hasegawa, Hiroshi Kanai, Kohji Fukunaga
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 131 Pages: 172-183

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Accurate evaluation of viscoelasticity of radial artery wall during flow-mediated dilation in ultrasound measurement2016

    • Author(s)
      Yasumasa Sakai, Hirofumi Taki and Hiroshi Kanai
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55

    • NAID

      210000146836

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Estimation of size of red blood cell aggregates using backscattering property of high-frequency ultrasound: In vivo evaluation2016

    • Author(s)
      Yusaku Kurokawa, Hirofumi Taki, Satoshi Yashiro, Kan Nagasawa, Yasushi Ishigaki and Hiroshi Kanai
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55

    • NAID

      210000146837

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Three-dimensional visualization of shear wave propagation generated by dual acoustic radiation pressure2016

    • Author(s)
      Yuta Mochizuki, Hirofumi Taki and Hiroshi Kanai
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55

    • NAID

      210000146838

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 位相差トラッキング法2016

    • Author(s)
      10.宮下 進,室月 淳,室本 仁,小澤克典,長谷川英之,金井 浩
    • Journal Title

      Jpn J Med Ultrasonics

      Volume: 43 Pages: 483-490

    • NAID

      130005151399

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 糖尿病患者における超音波錯乱特性解析で推定された赤血球凝集体サイズに関する検討2017

    • Author(s)
      榊 紘輝,瀧 宏文,八代 諭,長澤 幹,石垣 泰,金井 浩
    • Organizer
      日本音響学会2017年春季研究発表会
    • Place of Presentation
      明治大学生田キャンパス,川崎市
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
  • [Presentation] 糖尿病患者における超音波散乱特性解析で推定された赤血球凝集体サイズに関する検討2017

    • Author(s)
      榊 紘輝, 瀧 宏文, 八代 諭, 長澤 幹, 石垣 泰, 金井 浩
    • Organizer
      日本音響学会2017年春季研究発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 超音波散乱特性の計測による糖尿病患者の赤血球集合度評価2017

    • Author(s)
      榊 紘輝, 荒川元孝, 八代諭, 石垣泰, 金井 浩
    • Organizer
      第1回先端超音波シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 赤血球集合に着目した糖尿病患者に対する超音波の散乱特性解析2017

    • Author(s)
      榊 紘輝, 荒川元孝, 八代諭, 石垣泰, 金井 浩
    • Organizer
      電子情報通信学会超音波研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 超音波散乱特性の解析による糖尿病患者の赤血球凝集度評価2017

    • Author(s)
      榊 紘輝, 荒川元孝, 八代諭, 石垣泰, 金井 浩
    • Organizer
      第38回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高周波超音波を用いた周波数特性による赤血球凝集サイズ計測と臨床応用2016

    • Author(s)
      黒川祐作,榊 紘輝,瀧 宏文,八代 諭,長澤 幹,石垣 泰,金井 浩
    • Organizer
      日本超音波医学会第89回学術集会
    • Place of Presentation
      京都国際会議場,京都市
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 超音波散乱パワー特性解析による赤血球凝集体サイズ長時間計測2016

    • Author(s)
      榊 紘輝 瀧 宏文,八代 諭,石垣 泰,金井 浩
    • Organizer
      日本超音波医学会第52回東北地方会学術集会
    • Place of Presentation
      秋田市にぎわい交流館AU,秋田市
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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