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Development of digital CW EPR spectrometer for in-vivo applications

Research Project

Project/Area Number 16K14275
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Measurement engineering
Research InstitutionOsaka University

Principal Investigator

Akaba Hideo  大阪大学, 基礎工学研究科, 准教授 (00552077)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords磁気共鳴分光器 / 電子スピン共鳴 / 生体EPRイメージング / 生体用電子スピン共鳴分光器 / デジタル電子スピン共鳴分光器 / 磁気共鳴分光法 / EPR / FPGA / デジタルEPR分光装置 / 自動同調・整合制御 / ESR / 電子スピン共鳴分光法 / 生体イメージング
Outline of Final Research Achievements

The goal of the present work was developing a digital electron spin resonance (EPR) spectrometer aiming at high sensitivity and low cost. We succeeded in acquiring magnetic resonance signal by continuous wave EPR method by fabricating an FPGA receiver board that can acquire high frequency signal of L-band without frequency conversion. In addition, we proposed a new digital automatic suppression control method of reflected wave, and verified it using the signal-processing algorithm implemented on the FPGA. As a result, we successfully developed a digital EPR spectrometer that can operate stably to acquire EPR signals from living animals.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2017 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Design and testing of a 750MHz CW-EPR digital console for small animal imaging.2017

    • Author(s)
      Sato-Akaba H, Emoto MC, Hirata H, Fujii HG
    • Journal Title

      J Magn Reson.

      Volume: 284 Pages: 48-58

    • DOI

      10.1016/j.jmr.2017.09.008

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Brain redox imaging using blood-brain-barrier nitroxides by digital EPR imaging system2017

    • Author(s)
      Miho C. Emoto, Hideo Sato-Akaba, Hirotada G. Fujii
    • Organizer
      The ISMRM 25th Annual Meeting & Exhibition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体用デジタルCW-EPR イメージング装置の開発2017

    • Author(s)
      赤羽 英夫
    • Organizer
      第56回電子スピンサイエンス学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生体計測用L-band整合同調回路の開発2017

    • Author(s)
      濱垣研太, 宮戸祐治, 赤羽英夫
    • Organizer
      第56回電子スピンサイエンス学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] CW-EPR 生体イメージング用磁場制御電源の開発2016

    • Author(s)
      大野将希, 宮戸祐治, 赤羽英夫
    • Organizer
      第55回電子スピンサイエンス学会年会
    • Place of Presentation
      大阪市立大学杉本キャンパス(大阪府・大阪市)
    • Year and Date
      2016-11-10
    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 電子スピン共鳴装置2017

    • Inventor(s)
      赤羽英夫, 藤井博匡, 江本美穂
    • Industrial Property Rights Holder
      赤羽英夫, 藤井博匡, 江本美穂
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 電子スピン共鳴装置2017

    • Inventor(s)
      赤羽英夫、藤井博匡、江本美穂
    • Industrial Property Rights Holder
      赤羽英夫、藤井博匡、江本美穂
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-050576
    • Filing Date
      2017-03-15
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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