| Project/Area Number |
16K14325
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Civil and environmental engineering
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 水系感染症ウイルス / 消毒耐性ウイルス / 熱処理 / 塩素処理 / 感染性評価手法 / PCR法 / PMAxx-Enhancer-PCR法 / 消毒不活化メカニズム / PMAxx-PCR法 / プラック形成法 / 消毒処理 / 精密質量分析 / カプシドタンパク質 |
|---|
| Outline of Final Research Achievements |
The objective of this study was to elucidate the virus disinfection mechanism and the disinfection resistance mechanism by analysis of damage of viral capsid protein constituting virus particles. As a result, it was revealed that the damage of the capsid protein is the main cause of inactivation of adenovirus, coxsackievirus and pepper mild mottle virus in heat treatment. In contrast, it was suggested that not only the damage of the capsid protein but also mild oxidation and/or chlorination of the capsid protein probably contribute to inactivation of those viruses in chlorine treatment.
|
