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Consideration of design principle for creating implant that does not cause strain shielding on bone based on bone matrix orientation

Research Project

Project/Area Number 16K14418
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Structural/Functional materials
Research InstitutionOsaka University

Principal Investigator

Ishimoto Takuya  大阪大学, 工学研究科, 准教授 (50508835)

Co-Investigator(Kenkyū-buntansha) 中野 貴由  大阪大学, 工学研究科, 教授 (30243182)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsひずみ遮蔽 / 配向性 / 金属インプラント / 低ヤング率インプラント / 骨ヤング率 / 骨細胞 / インプラント / アパタイト配向性 / 減荷 / 骨インプラント
Outline of Final Research Achievements

Metallic implant that does not cause strain shielding has been keenly anticipated because strain shielding in which the mechanical stimuli required enough for maintaining bone health is lost results not only in bone loss but also in reduced bone strength. To achieve such implant, basic study is needed for understanding the relationship between strain shielding and bone matrix orientation. We prepared the strain shielding situations with and without using implant and analyzed the bone matrix orientation and bone mechanical property, resulting in clarifying that the strain shielding surely induced the deterioration of bone matrix orientation and mechanical property simultaneously. However, mitigation of strain shielding by using low-modulus implant significantly reduced the degree of deterioration of bone matrix orientation and mechanical property.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2018 2017 2016

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (3 results) (of which Invited: 2 results)

  • [Journal Article] Unloading-induced degradation of the anisotropic arrangement of collagen/apatite in rat femurs2017

    • Author(s)
      Jun Wang, Takuya Ishimoto and Takayoshi Nakano
    • Journal Title

      Calcified Tissue International

      Volume: 100 Issue: 1 Pages: 87-94

    • DOI

      10.1007/s00223-016-0200-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] アパタイト配向性と骨のメカノバイオロジー2016

    • Author(s)
      石本卓也, 中野貴由
    • Journal Title

      バイオマテリアル‐生体材料‐

      Volume: 34 Pages: 138-143

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Additive manufacturingによる低ヤング率インプラントの創製と骨への応力遮蔽抑制効果2018

    • Author(s)
      石本卓也、中野貴由、川西洋平、阿部信吾、坂井孝司、村瀬剛、吉川秀樹
    • Organizer
      第38回日本骨形態計測学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 応力応答性に骨質を支配するアパタイト結晶配向性2016

    • Author(s)
      石本卓也, 中野貴由
    • Organizer
      日本補綴歯科学会第125回学術大会
    • Place of Presentation
      石川県立音楽堂
    • Year and Date
      2016-07-08
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 骨の配向性解析と、配向化を促す骨インプラント2016

    • Author(s)
      石本卓也, 中野貴由
    • Organizer
      第55回日本生体医工学会大会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2016-04-26
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2019-03-29  

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