Consideration of design principle for creating implant that does not cause strain shielding on bone based on bone matrix orientation
| Project/Area Number |
16K14418
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Structural/Functional materials
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中野 貴由 大阪大学, 工学研究科, 教授 (30243182)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ひずみ遮蔽 / 配向性 / 金属インプラント / 低ヤング率インプラント / 骨ヤング率 / 骨細胞 / インプラント / アパタイト配向性 / 減荷 / 骨インプラント |
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| Outline of Final Research Achievements |
Metallic implant that does not cause strain shielding has been keenly anticipated because strain shielding in which the mechanical stimuli required enough for maintaining bone health is lost results not only in bone loss but also in reduced bone strength. To achieve such implant, basic study is needed for understanding the relationship between strain shielding and bone matrix orientation. We prepared the strain shielding situations with and without using implant and analyzed the bone matrix orientation and bone mechanical property, resulting in clarifying that the strain shielding surely induced the deterioration of bone matrix orientation and mechanical property simultaneously. However, mitigation of strain shielding by using low-modulus implant significantly reduced the degree of deterioration of bone matrix orientation and mechanical property.
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Report
(3 results)
Research Products
(5 results)
