Virus sensing based on infectivity using biological membrane structure control protein
| Project/Area Number |
16K14488
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大河内 美奈 東京工業大学, 物質理工学院, 教授 (70313301)
早水 裕平 東京工業大学, 物質理工学院, 准教授 (80443216)
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| Research Collaborator |
Evans Stephen University of Leeds, School of Physics and Astronomy
Chritchley Kevin University of Leeds, School of Physics and Astronomy
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Virus sensor / cell membrane / biomimetics / peptide array / ウイルスセンサ / インフルエンザウイルス / 生体膜 / ペプチド / 金ナノ粒子 / バイオセンサー / ウイルス |
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| Outline of Final Research Achievements |
We investigated the development of a new electrochemical virus sensor with virus infection as an indicator by covering a conductive element with a biological membrane that mimics cell membranes. According to the original research plan, various functional peptides including sensor element binding peptide, biological membrane binding peptide and virus binding peptide were identified and applied for the sensor development. Using these peptides with pore sensor electrochemical devise, it was successfully shown that one influenza virus can be detected with the potential of the species identification. By carrying out detailed comparative analysis between active and inactive viruses, new reliable virus sensing devices without false positive detection can be developed in near future.
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Report
(3 results)
Research Products
(11 results)
