Synthesis of the ligand that chelate a radium and disintegrated nucleus for nuclear medicine

Research Project

Project/Area Number	16K14537
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Nuclear engineering
Research Institution	Osaka University
Principal Investigator	Yoshimura Takashi 大阪大学, ラジオアイソトープ総合センター, 教授 (90323336)
Co-Investigator(Kenkyū-buntansha)	永田光知郎大阪大学, ラジオアイソトープ総合センター, 助教 (10806871)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords	ラジウム / キレート / アルファ線 / 多座配位子 / 鉛 / バリウム / ストロンチウム / アルカリ土類金属 / 安定度定数 / 合成化学 / 配位子 / 放射線
Outline of Final Research Achievements	Chelate ligands which fit into the ionic radius of radium ion were synthesized. The single-crystal X-ray analysis was succeeded to perform for the complexes of Cs and Rb whose ionic radii are similar to Ra, and those of Ba, Sr, Ca, and Pb. A trend that the stability constant become larger with increasing ionic radius was observed in Ca, Sr, and Ba by using the 10-coordinate ligand. In the case using Pb, a very large stability constant value was obtained. Therefore, it was found that the ligand can effectively chelate Pb that is decay product of Ra. The reaction of Ra with the ligand gave the complex in high yield.