Mechanisms of neuronal cell death and survival
Project/Area Number |
16K14567
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Nerve anatomy/Neuropathology
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Research Institution | Keio University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
HONDA Takao 慶應義塾大学, 医学部, 講師 (30365225)
KUBO Ken-ichiro 慶應義塾大学, 医学部, 講師 (20348791)
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Project Period (FY) |
2016-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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Keywords | 神経科学 / 脳・神経 / 発生・分化 / 細胞死 |
Outline of Final Research Achievements |
We found that massive neuronal cell death occurred during culture of mouse cerebral cortex and that a certain component in the culture medium was important for this cell death induction. We have therefore analyzed the mechanism of this cell death, and have discovered a drug that could prevent the cell death by inhibiting this mechanism. We have also identified a set of genes whose expression was changed dramatically when mouse embryos had been exposed to transient ischemia.
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Report
(2 results)
Research Products
(11 results)
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[Journal Article] Association of impaired neuronal migration with cognitive deficits in extremely preterm infants.2017
Author(s)
Ken-ichiro Kubo, K. Deguchi, T. Nagai, Y. Ito, K. Yoshida, T. Endo, S. Benner, W.Shan, A. Kitazawa, M. Aramaki, K. Ishii, M. Shin, Y. Matsunaga, K. Hayashi, M. Kakeyama, C. Tohyama, K.F. Tanaka, K. Tanaka, S. Takashima, M. Nakayama, M. Itoh, Y. Hirata, B. Antalffy, D.D. Armstrong, K. Yamada, K. Inoue, Kazunori Nakajima
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Journal Title
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Why does cognitive impairment frequently develop later in extremely preterm infants?2016
Author(s)
Ken-ichiro Kubo, Kimiko Deguchi, Taku Nagai, Wei Shan, Ayako Kitazawa, Michihiko Aramaki, Kazuhiro Ishii, Shin Minkyung, Sachio Takashima, Masahiro Nakayama, Masayuki Itoh, Barbara Antalffy, Dawna D. Armstrong, Kiyofumi Yamada, Ken Inoue, and Kazunori Nakajima
Organizer
Cell Symposia: Big Questions in Neuroscience
Place of Presentation
San Diego(U.S.A.)
Year and Date
2016-11-10
Related Report
Int'l Joint Research
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