Mechanisms of neuronal cell death and survival

• Project/Area Number: 16K14567
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Keio University
• Principal Investigator: NAKAJIMA Kazunori 慶應義塾大学, 医学部(信濃町), 教授 (90280734)
• Co-Investigator(Renkei-kenkyūsha): HONDA Takao 慶應義塾大学, 医学部, 講師 (30365225) ; KUBO Ken-ichiro 慶應義塾大学, 医学部, 講師 (20348791)
• Project Period (FY): 2016-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 神経科学 / 脳・神経 / 発生・分化 / 細胞死

Outline of Final Research Achievements

We found that massive neuronal cell death occurred during culture of mouse cerebral cortex and that a certain component in the culture medium was important for this cell death induction. We have therefore analyzed the mechanism of this cell death, and have discovered a drug that could prevent the cell death by inhibiting this mechanism.
We have also identified a set of genes whose expression was changed dramatically when mouse embryos had been exposed to transient ischemia.

Research Products

• [Int'l Joint Research] ベイラー医科大学(米国)
• [Journal Article] Association of impaired neuronal migration with cognitive deficits in extremely preterm infants. (2017)
  • Author(s): Ken-ichiro Kubo, K. Deguchi, T. Nagai, Y. Ito, K. Yoshida, T. Endo, S. Benner, W.Shan, A. Kitazawa, M. Aramaki, K. Ishii, M. Shin, Y. Matsunaga, K. Hayashi, M. Kakeyama, C. Tohyama, K.F. Tanaka, K. Tanaka, S. Takashima, M. Nakayama, M. Itoh, Y. Hirata, B. Antalffy, D.D. Armstrong, K. Yamada, K. Inoue, Kazunori Nakajima
  • Journal Title: JCI Insight Volume: 印刷中
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Novel ALS/FTD model mice expressed cytoplasmic FUS in a toxic gain-of-function manner (2017)
  • Author(s): Gen Shiihashi, Daisuke Ito, Yuki Kobayashi, Shigeyoshi Itohara, Kanehiro Hayashi, Kazunori Nakajima, Shintaro Otsuka, Michisuke Yuzaki, and Norihiro Suzuki
  • Organizer: The 13th International Conference on Alzheimer’s and Parkinson’s Diseases
  • Place of Presentation: Vienna (Austria)
  • Year and Date: 2017-03-29
  • Int'l Joint Research
• [Presentation] 超早産児脳障害のモデルマウス脳における組織構築の解析 (2017)
  • Author(s): 久保健一郎、出口貴美子、北澤彩子、石井一裕、シン ミンギョン、高嶋幸男、中山雅弘、伊藤雅之、井上健、仲嶋一範
  • Organizer: 第122回日本解剖学会総会・全国学術集会
  • Place of Presentation: 長崎大学坂本キャンパス（長崎県長崎市）
  • Year and Date: 2017-03-28
• [Presentation] Neuronal layer formation during development of the cerebral cortex (2017)
  • Author(s): Kazunori Nakajima
  • Organizer: NUS-KEIO JOINT SCIENTIFIC SYMPOSIUM “Frontiers of Translational Medicine -From Cradle to Ageing”
  • Place of Presentation: Singapore
  • Year and Date: 2017-01-10
  • Int'l Joint Research / Invited
• [Presentation] Why does cognitive impairment frequently develop later in extremely preterm infants? (2016)
  • Author(s): Ken-ichiro Kubo, Kimiko Deguchi, Taku Nagai, Wei Shan, Ayako Kitazawa, Michihiko Aramaki, Kazuhiro Ishii, Shin Minkyung, Sachio Takashima, Masahiro Nakayama, Masayuki Itoh, Barbara Antalffy, Dawna D. Armstrong, Kiyofumi Yamada, Ken Inoue, and Kazunori Nakajima
  • Organizer: Cell Symposia: Big Questions in Neuroscience
  • Place of Presentation: San Diego(U.S.A.)
  • Year and Date: 2016-11-10
  • Int'l Joint Research
• [Presentation] 大脳皮質層構造の形成機構 (2016)
  • Author(s): 仲嶋一範
  • Organizer: 京都大学医学部解剖学特別講義
  • Place of Presentation: 京都大学医学部総合解剖センター（京都府京都市）
  • Invited
• [Presentation] 大脳皮質構築のメカニズム (2016)
  • Author(s): 仲嶋一範
  • Organizer: 京都大学大学院医学研究科セミナー
  • Place of Presentation: 京都大学医学部A棟（京都府京都市）
  • Invited
• [Presentation] 環境因子が大脳皮質の発生・発達過程に与える影響 (2016)
  • Author(s): 仲嶋一範
  • Organizer: 九州大学精神科・特別セミナー
  • Place of Presentation: 九州大学病院ウェストウィング棟（福岡県福岡市）
  • Invited
• [Presentation] 大脳皮質の形成機構 (2016)
  • Author(s): 仲嶋一範
  • Organizer: 九州大学医学部組織学特論
  • Place of Presentation: 九州大学病院キャンパス基礎研究B棟（福岡県福岡市）
  • Invited
• [Presentation] 環境要因としての虚血ストレスが大脳皮質の発達に与える影響（Effects of ischemic stress on cerebral cortical development） (2016)
  • Author(s): 久保健一郎、出口貴美子、井澤栄一、井上健、仲嶋一範
  • Organizer: フォーラム2016：衛生薬学・環境トキシコロジー,シンポジウム：“生体防御・ストレス応答研究の新展開”
  • Place of Presentation: 昭和大学旗の台キャンパス（東京都品川区）
  • Invited