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Development of photo-responsive biomaterials mimicking brain microenvironment

Research Project

Project/Area Number 16K14577
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurochemistry/Neuropharmacology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Ajioka Itsuki  東京医科歯科大学, 統合研究機構(脳統合機能研究センター), 准教授 (10348790)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords脳発生 / 生体適合性材料 / 微小環境 / 血管 / 生体材料 / 再生医学
Outline of Final Research Achievements

In the development, the pathology, and the regeneration of the brain, a microenvironment plays an important role in regulating cellular functions by assembling specific extracellular matrix and growth factors. In this study, we aimed to develop an artificial scaffold mimicking the microenvironment and regulating cellular functions by photo-stimulation. We developed peptide-based scaffolds that are soluble in tube but form fiber after in vivo injection. We also developed peptide-based scaffolds immobilized light-sensitive protein.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2018 Other

All Presentation (1 results) (of which Invited: 1 results) Remarks (2 results)

  • [Presentation] 人工足場創製によるin vivo脳組織工学2018

    • Author(s)
      味岡逸樹
    • Organizer
      第17回日本再生医療学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Remarks] 味岡研究グループ

    • URL

      http://www.tmd.ac.jp/cbir/1/ajioka/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 味岡研究グループ/脳統合機能研究センター

    • URL

      http://www.tmd.ac.jp/cbir/1/ajioka/index.html

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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