| Project/Area Number |
16K14599
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
Takada Toyoyuki 国立遺伝学研究所, 系統生物研究センター, 助教 (20356257)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 疾患モデル / 摂食行動 / 肥満 / 脂肪蓄積 |
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| Outline of Final Research Achievements |
In mammals, energy metabolism-related traits including site-specific fat depositions are governed by complex genetic and environmental factors. In this study, we intend to uncover the genetic determinants that control site-specific fat depositions with mouse inter-subspecific consomic strains, B6-ChrNMSM. At first we conducted generating double consomic strains using several consomic strains that have specific features of site-specific fat depositions. We also conducted the analysis of gene expression profiles from fat-deposition related tissues of several designated consomic strains. In this study, we have succeeded generate founder animals of several double consomic strains, and found some candidate genes that are relevant to site-specific fat depositions. We expect that the results of this project would useful for the study of finding important genes for genetically controlling site-specific fat depositions in mammals.
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