| Project/Area Number |
16K14602
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Hokkaido University |
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Principal Investigator |
Miura Kyoko 北海道大学, 遺伝子病制御研究所, 准教授 (80583062)
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| Co-Investigator(Kenkyū-buntansha) |
坊農 秀雅 大学共同利用機関法人情報・システム研究機構(機構本部施設等), 大学共同利用機関等の部局等, 准教授 (20364789)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU Atsushi 岩手医科大学, いわて東北メディカル・メガバンク機構, 教授 (30327655)
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| Research Collaborator |
OIWA Yuki 北海道大学, 遺伝子病制御研究所, 大学院生
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ハダカデバネズミ / naked mole rat / がん / 細胞老化 / ARF |
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| Outline of Final Research Achievements |
The naked mole rat (NMR) is the longest-living rodent in the world and has extraordinary cancer-resistance. We studied the mechanisms of NMR-specific tumor-suppressive phenomenon, ASIS (ARF suppression-induced senescence). We performed mRNA-seq analyses and found the genes which are upregulated or downregulated upon ASIS induction. We also found NMR-specific regulation of signal transduction in ASIS.
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