Induction of chromosomal instability by aberrant expression of motor proteins working on the spindle
| Project/Area Number |
16K14604
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Tohoku University |
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Principal Investigator |
Tanaka Kozo 東北大学, 加齢医学研究所, 教授 (00304452)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEDA Masanori 東北大学, 加齢医学研究所, 教育研究支援者 (80645010)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 癌 / 細胞・組織 / 染色体不安定性 |
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| Outline of Final Research Achievements |
Chromosomal instability, which is found in most cancer cells, is supposedly caused by defects permissive for cell survival. As causes of such mild defects, we focused on motor proteins that regulates chromosome dynamics on the spindle, and investigated the relationship between dysregulated expression of these proteins and chromosomal instability. When we reduced the expression of motor-related proteins on the spindle, time required to align chromosomes to the spindle equator was elongated, and chromosomal instability was induced. We also found that the late-aligning chromosomes are prone to show abnormal kinetochore-microtubule attachment as well as chromosome missegregation. These results suggest that delay in chromosome alignment causes chromosomal instability.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Phosphorylation of BACH1 switches its function from transcription factor to mitotic chromosome regulator and promotes its interaction with HMMR.2018
Author(s)
Li J, Shima H, Nishizawa H, Ikeda M, Brydun A, Matsumoto M, Kato H, Saiki Y, Liu L, Watanabe-Matsui M, Iemura K, Tanaka K, Shiraki T, Igarashi K.
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Journal Title
Biochemical Journal
Volume: 475
Issue: 5
Pages: 981-1002
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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