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Elucidation of T cell infiltration mechanism into the tumor tissue by the antigen recognition

Research Project

Project/Area Number 16K14611
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Tumor biology
Research InstitutionKochi University

Principal Investigator

Komatsu Toshihiro  高知大学, 教育研究部医療学系基礎医学部門, 助教 (90598517)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords血管内皮細胞 / 抗原提示 / 腫瘍抗原 / 細胞傷害性T細胞 / MHC class I 分子 / T細胞 / 腫瘍 / 免疫学 / 腫瘍細胞
Outline of Final Research Achievements

In this study, we found that cross-presentation of tumor antigen by tumor endothelial cells(tECs) promotes infiltration of tumor specific CTLs in tumors. We developed in vivo method to evaluate the infiltration of tumor specific CTLs in tumors by recognition of tumor antigen on tECs. We found that material “X” which promotes cross-presentation by tEC induced strong tumor regression.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2018 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (6 results)

  • [Journal Article] Knockout of the interleukin-36 receptor protects against renal ischemia-reperfusion injury by reduction of proinflammatory cytokines2018

    • Author(s)
      Nishikawa H, Taniguchi Y, Matsumoto T, Arima N, Masaki M, Shimamura Y, Inoue K, Horino T, Fujimoto S, Ohko K, Komatsu T, Udaka K, Sano S, Terada Y.
    • Journal Title

      Kidney Int.

      Volume: 93 Issue: 3 Pages: 599-614

    • DOI

      10.1016/j.kint.2017.09.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improvement of Peptide-Based Tumor Immunotherapy Using pH-Sensitive Fusogenic Polymer-Modified Liposomes.2016

    • Author(s)
      Yoshizaki Y, Yuba E, Komatsu T, Udaka K, Harada A, Kono K
    • Journal Title

      Molecules

      Volume: 21 Issue: 10 Pages: 1284-1284

    • DOI

      10.3390/molecules21101284

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 固形腫瘍内へのT細胞の浸潤機構2018

    • Author(s)
      小松 利広
    • Organizer
      新学術領域研究「ネオ・セルフの生成・機能・構造」 第1回 若手の会(第2回 領域班会議)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Extravasation of CTLs occurs by recognizing the MHC-peptide complexes cross-presented by vascular endothelial cells2017

    • Author(s)
      Toshihiro Komatsu, Ryosuke Iwade, Mika Kijima, Takehito Sato, Keiko Udaka
    • Organizer
      第46回日本免疫学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Construction of a TAP deficient HLA class I-binding assay system with the use of CRISPR/Cas9 system2017

    • Author(s)
      Takeyuki Shimizu, Toshihiro Komatsu, Keiko Udaka
    • Organizer
      第46回日本免疫学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cross-presentation of tumor antigen by endothelial cells promotes infiltration of tumor specific CTLs2016

    • Author(s)
      Komatsu T, Iwade R, Sato T, Udaka K
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report
  • [Presentation] 血管内皮細胞のHLAクラスII発現は、T細胞浸潤及び膵腫瘍に対する傷害活性と関連する2016

    • Author(s)
      宇高 恵子、木岐 淳、西森 功、西原 利治、小松 利広、西岡 千恵、鈴木 勝英
    • Organizer
      第8回血液疾患免疫療法学会学術集会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2016-09-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 血管内皮細胞のクロスプレゼンテーションによるCTLの固形腫瘍への抗原特異的浸潤2016

    • Author(s)
      岩出 良介、横山 水紀、小松 利広、木嶋 美香、笠井 道之、清水 健之、佐藤 健人、宇高 恵子
    • Organizer
      第15回四国免疫フォーラム
    • Place of Presentation
      高知大学(高知県南国市)
    • Year and Date
      2016-06-25
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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