| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
“Countenances of cancer” is a word that describes degrees of cancer malignancy, especially in breast cancers. Although grades of malignancy in “countenances of cancer” are generally rated based on, partly, the percentage of nuclei with aberrant morphology, little is known about the mechanisms involved in exhibiting aberrant nuclear morphology in cancer cells. In this study, we analyzed the action mechanisms of the natural compound 2057 that induced aberrant nuclear morphology, such as nuclear lobulation. As a result, we revealed that protein kinase C, RNA binding protein YB-1 and tubulin play essential roles in nuclear lobulation induced by 2057. In addition, as a first step toward developing novel anti-cancer drugs, we isolated compounds that inhibit 2057-induced nuclear lobulation, restoring the nuclear morphology to the normal oval-like form.
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