Active glucose metabolism and tumor promotion mediated by Pkm1
| Project/Area Number |
16K14621
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Miyagi Prefectural Hospital Organization Miyagi Cancer Center |
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Principal Investigator |
TANUMA Nobuhiro 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 主任研究員 (40333645)
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| Project Period (FY) |
2016-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | Pkm / グルコース代謝 / オートファジー / がん細胞の特性 |
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| Outline of Final Research Achievements |
In this study, we explored how Pkm1 promotes tumor growth/survival. We found that the mode of Pkm1's action is tumor cell-intrinsic. Pkm1-expressing cells combine active TCA cycle and lower ROS levels in mitochondria through mitophagy. Importantly, this metabolic rewiring by Pkm1 impedes neither pentose phosphate pathway nor purine synthesis. Our results unveil tumor-promoting function of Pkm1.
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Report
(2 results)
Research Products
(7 results)
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[Journal Article] The protein phosphatase 6 catalytic subunit (Ppp6c) is indispensable for proper post-implantation embryogenesis.2016
Author(s)
Ogoh, H., Tanuma, N., Matsui, Y., Hayakawa, N., Inagaki, A., Sumiyoshi, M., Momoi, Y., Kishimoto, A., Suzuki, M., Sasaki, N., Ohuchi, T., Nomura, M., Teruya, Y., Yasuda, K., Watanabe, T., Shima, H.
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Journal Title
Mechanisms of Development
Volume: 139
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access
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