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Development of novel cancer diagnostic method by detection of sugar chain in urine using glycomics analysis

Research Project

Project/Area Number 16K14624
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Tumor diagnostics
Research InstitutionSapporo Medical University

Principal Investigator

Kato Junji  札幌医科大学, 医学部, 教授 (20244345)

Co-Investigator(Kenkyū-buntansha) 村瀬 和幸  札幌医科大学, 医学部, 助教 (90444918)
松野 鉄平  札幌医科大学, 医学部, 研究員 (60774221)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsフコシル化 / biomarker / グライコミクス / 膵癌
Outline of Final Research Achievements

Changes in sugar chain structure of cell surface and secreted glycoprotein are well known as one of the characteristics of cancer cells. In the blood examination, blood antigens in which fucose is added to the sugar chain are measured as tumor markers like CA19-9.
In this study, we developed a new diagnostic method for the presence of cancer by detecting fucosylated oligosaccharides from urine of patients with cancer by using glycomics technology.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2016

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 5 results)

  • [Journal Article] Activated p53 with Histone Deacetylase Inhibitor Enhances L-Fucose-Mediated Drug Delivery through Induction of Fucosyltransferase 8 Expression in Hepatocellular Carcinoma Cells.2016

    • Author(s)
      Okagawa Y, Murase K, Kato J, et al
    • Journal Title

      PLoS One.

      Volume: 15 Issue: 12 Pages: e0168355-e0168355

    • DOI

      10.1371/journal.pone.0168355

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A phase II trial of small-dose bortezomib, lenalidomide and dexamethasone (sVRD) as consolidation/maintenance therapy in patients with multiple myeloma.2016

    • Author(s)
      Ibata S, Kato J, et al.
    • Journal Title

      Cancer Chemother Pharmacol.

      Volume: 78 Pages: 1041-1049

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeting Notch-1 positive acute leukemia cells by novel fucose-bound liposomes carrying daunorubicin.2016

    • Author(s)
      Ono M, Kato J, et al.
    • Journal Title

      Oncotarget.

      Volume: 21 Issue: 25 Pages: 38586-38597

    • DOI

      10.18632/oncotarget.9558

    • NAID

      120006576952

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship Between Increased Fucosylation and Metastatic Potential in Colorectal Cancer.2016

    • Author(s)
      Osuga T, Kato J, et al.
    • Journal Title

      J Natl Cancer Inst.

      Volume: 14 Issue: 9 Pages: djw210-djw210

    • DOI

      10.1093/jnci/djw210

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/β-catenin signaling in human multiple myeloma.2016

    • Author(s)
      Kamihara Y, Murase K, Kato J, et al
    • Journal Title

      Oncotarget

      Volume: 27 Issue: 39 Pages: 64330-64341

    • DOI

      10.18632/oncotarget.11830

    • NAID

      120006576953

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research

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Published: 2016-04-21   Modified: 2019-03-29  

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