Body on a Chip as an in-vitro model of endangered animals
| Project/Area Number |
16K14660
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservation of biological resources
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
平井 義和 京都大学, 工学(系)研究科(研究院), 研究員 (40452271)
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| Co-Investigator(Renkei-kenkyūsha) |
Murayama Miho 京都大学, 野生動物研究センター, 教授 (60293552)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | Body on a Chip / iPS細胞 / マイクロ流体デバイス / 絶滅危惧種 / 動物保全 / リプログラミング / 分化 / マイクロ・ナノデバイス / 動物 / 細胞・組織 / 獣医学 |
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| Outline of Final Research Achievements |
The objective in this study is to develop "Body on a Chip" as an in-vitro model of endangered animals by utilizing technologies to develop induced pluripotent stem (iPS) cells and microfluidics, to elucidate their physiology and pathology. To accomplish this goal, we proposed three specific aims; A. to generate iPS cells from endangered animals, B. to establish the protocols to induce the differentiation to specific tissues from established iPS cells from endangered animals, C. to develop a "Body on a Chip" platform with the tissue cells derived from from endangered animals.
The achievements of this study will lead us to understand the unique and unclear mechanisms of animal diseases and find to cure those diseases. It would be a great step towards animal life conservation.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Microfluidic-nanofiber hybrid array for screening of cellular microenvironments2017
Author(s)
K. Kamei, Y. Mashimo, M. Yoshioka, Y. Tokunaga, C. Fockenberg, S. Terada, M. Nakajima, T. Shibata-Seki, L. Liu, T. Akaike, E. Kobatake, E. S. How, M. Uesugi and Y. Chen
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Journal Title
Small
Volume: 印刷中
Issue: 18
Pages: 1603104-1603104
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Nano-on-micro fibrous extracellular matrices for scalable expansion of human ES/iPS cells2017
Author(s)
Li Liu, Ken-ichiro Kamei, Momoko Yoshioka, Minako Nakajima, Junjun Li, Nanae Fujimoto Shiho Terada, Yumie Tokunaga, Yoshie Koyama, Hideki Sato, Koichi Hasegawa, Norio Nakatsuji, Yong Chen
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Journal Title
Biomaterial
Volume: 124
Pages: 47-54
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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