| Project/Area Number |
16K14676
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | National Institutes of Biomedical Innovation, Health and Nutrition |
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Principal Investigator |
OKA Masahiro 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 細胞核輸送ダイナミクスプロジェクト, プロジェクトリーダー (40432504)
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| Co-Investigator(Renkei-kenkyūsha) |
OHKAWA Yasuyuki 九州大学, 生体防御医学研究所, 教授 (80448430)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Crm1 / Hoxクラスター / 核外輸送因子 / 細胞分化 / クロマチン / 発現制御 / 細胞・組織 / 発生・分化 / Hox遺伝子 |
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| Outline of Final Research Achievements |
Our research revealed that the genome-wide binding pattern of Crm1, a nuclear export factor, dynamically changes during cell differentiation. Our work also suggests that the chromatin-bound Crm1 could interact with various proteins, including chromatin regulatory factors, and is possibly involved in the epigenetic regulation.
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