Studies on RNA degradation by autophagy for cell survival during starvation
| Project/Area Number |
16K14691
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Suzuki Kuninori 東京大学, 大学院新領域創成科学研究科, 准教授 (20373194)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | オートファジー / オートファゴソーム / RNA分解 / 栄養飢餓 / 出芽酵母 / オートファジックボディ / RNA sequence / オルガネラ / Atgタンパク質 / タンパク質分解 / 隔離膜 / 膜動態 / RNA / Atg15 / 細胞・組織 / 核酸 / 分解 |
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| Outline of Final Research Achievements |
When eukaryotic cells face with nutrient starvation, they degrade their cytoplasmic materials to adapt the severe environment. Recently, it has been reported that autophagy contributes to degrade RNA in response to starvation. In this study, we aimed to make a list of RNA species selectively degraded by autophagy. We have established an overexpression system of Atg15, which is responsible for the final step of autophagic degradation.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Systematic analysis of Ca2+ homoeostasis in Saccharomyces cerevisiae based on chemical-genetic interaction profiles2017
Author(s)
Farzan Ghanegolmohammadi, Mitsunori Yoshida, Shinsuke Ohnuki, Yuko Sukegawa, Hiroki Okada, Keisuke Obara, Akio Kihara, Kuninori Suzuki, Tetsuya Kojima, Nozomu Yachie, Dai Hirata, Yoshikazu Ohya
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Journal Title
Mol. Biol. Cell
Volume: 28
Issue: 23
Pages: 3415-3427
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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