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Role of glycans in control of FGF23 and Klotho functions

Research Project

Project/Area Number 16K14695
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Functional biochemistry
Research InstitutionKyoto University

Principal Investigator

Oka Shogo  京都大学, 医学研究科, 教授 (60233300)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsαKlotho / FGF23 / HNK-1糖鎖 / 腎臓 / グルクロン酸転移酵素 / 糖鎖 / αKlothoタンパク質 / O型糖鎖
Outline of Final Research Achievements

αKlotho is predominantly expressed in kidney and has important roles in regulation of mineral metabolism including calcium. αKlotho is also known to act as a co-receptor for fibroblast growth factor 23 (FGF23). Mice lacking functional αKlotho protein exhibit phenotypes resembling human aging. α-Klotho is a type I membrane protein with two glucosidase-like domains in a extracellular region. It is, however, still unclear how these glucosidase-like domains are utilized for the klotho function since the essential glutamate residues for enzymatic activity are not conserved in αKlotho. In this study, we investigated the role of HNK-1 and its related glycans in the functional regulation for FGF23 and αKlotho.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (17 results)

All 2018 2017 2016

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 3 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] Ribosomal protein uS7/Rps5 serine-223 in protein kinase-mediated phosphorylation and ribosomal small subunit maturation2018

    • Author(s)
      Tomioka Makoto、Shimobayashi Mitsugu、Kitabatake Makoto、Ohno Mutsuhito、Kozutsumi Yasunori、Oka Shogo、Takematsu Hiromu
    • Journal Title

      SCIENTIFIC REPORT

      Volume: 8 Issue: 1 Pages: 1244-1244

    • DOI

      10.1038/s41598-018-19652-z

    • NAID

      120006510286

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of human natural killer-1 (HNK-1) carbohydrate in neuronal plasticity and disease.2017

    • Author(s)
      Morise J, Takematsu H, Oka S.
    • Journal Title

      Biochim. Biophys. Acta.

      Volume: 1861 Issue: 10 Pages: 2455-2461

    • DOI

      10.1016/j.bbagen.2017.06.025

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts.2017

    • Author(s)
      Nakagawa Y, Nishikimi T, Kuwahara K, Fujishima A, Oka S, Tsutamoto T, Kinoshita H, Nakao K, Cho K, Inazumi H, Okamoto H, Nishida M, Kato T, Fukushima H, Yamashita JK, Wijnen WJ, Creemers EE, Kangawa K, Minamino N, Nakao K, Kimura T.
    • Journal Title

      J Am Heart Assoc.

      Volume: 6 Issue: 2

    • DOI

      10.1161/jaha.116.003601

    • NAID

      120007100125

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dystroglycan glycosylation: structure, synthetic pathway, and in vivo role in the brain development2016

    • Author(s)
      Nakagawa N and Oka S
    • Journal Title

      生化学

      Volume: 88 Issue: 4 Pages: 488-491

    • DOI

      10.14952/SEIKAGAKU.2016.880488

    • NAID

      40020948090

    • ISSN
      0037-1017
    • Year and Date
      2016-08-25
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Psychosine-triggered endomitosis is modulated by membrane sphingolipids through regulation of phosphoinositide 4,5-bisphosphate production at the cleavage furrow.2016

    • Author(s)
      Watanabe H, Okahara K, Naito-Matsui Y, Abe M, Go S, Inokuchi J, Okazaki T,Kobayashi T, Kozutsumi Y, Oka S, Takematsu H.
    • Journal Title

      Mol Biol Cell.

      Volume: 27 Issue: 13 Pages: 2037-2050

    • DOI

      10.1091/mbc.e15-08-0555

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced intake of carbohydrate prevents the development of obesity and impaired glucose metabolism in ghrelin O-acyltransferase knockout mice.2016

    • Author(s)
      Kouno T, Akiyama N, Fujieda K, Nanchi I, Okuda T, Iwasaki T, Oka S, Yukioka H.
    • Journal Title

      Peptides

      Volume: 86 Pages: 145-152

    • DOI

      10.1016/j.peptides.2016.11.003

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ghrelin O-acyltransferase knockout mice show resistance to obesity when fed high-sucrose diet.2016

    • Author(s)
      T. Kouno, N. Akiyama, T. Ito, T. Okuda, I. Nanchi, M. Notoya, S. Oka and H. Yukioka
    • Journal Title

      J Endocrinol.

      Volume: 228 Issue: 2 Pages: 115-125

    • DOI

      10.1530/joe-15-0330

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] N型糖鎖欠損体によるAMPA型グルタミン酸受容体の機構お解析2017

    • Author(s)
      森瀬譲二、鈴木健一、北川 英佳、山本 采季、竹内祐介、楠見明弘、竹松 弘、岡 昌吾
    • Organizer
      第18回関西グライコサイエンスフォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] AMPA型グルタミン酸受容体のN型糖鎖修飾は、4量体形成と細胞表面への移送を制御する2017

    • Author(s)
      Kandel Babu Munal、緑川 良介、岡 昌吾、川崎 ナナ、髙倉 大輔、髙宮 考悟
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ストレプトゾトシン誘導性腎機能障害マウスにおける非硫酸化型HNK-1糖鎖の発現解析2017

    • Author(s)
      北野仁望、森瀬譲二、岡昌吾
    • Organizer
      第57回日本臨床化学会年次学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 抗MAG抗体ニューロパチーにおける抗体affinityの継時的変化と臨床経過の比較2017

    • Author(s)
      松井太郎、濱田征宏、桑原基、森瀬譲二、岡昌吾、楠 進
    • Organizer
      第29回日本神経免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] イオンチャネル型グルタミン酸受容体に観察される糖鎖の厳密な発現制御2017

    • Author(s)
      岡 昌吾
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 胎生期にTenascin-C上に発現するHNK-1糖鎖の機能解析2016

    • Author(s)
      中村 綾沙、森瀬 譲二、竹松 弘、岡 昌吾
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター (宮城県)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
  • [Presentation] AMPA型グルタミン酸受容体サブユニットは神経細胞膜表面上を単量体で拡散する2016

    • Author(s)
      森瀬 譲二、鈴木 健一、北川 英佳、若園 佳彦、髙宮 考悟、楠見 明弘、竹松 弘、岡 昌吾
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター (宮城県)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 特定のN型糖鎖がAMPA型グルタミン酸受容体サブユニットGluA1の細胞内輸送を制御する2016

    • Author(s)
      山本 采季、森瀬 譲二、竹松 弘、岡 昌吾
    • Organizer
      第35回日本糖質学会年会
    • Place of Presentation
      高知市文化プラザ (高知県)
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
  • [Presentation] Identification of modifier genes that modulate cell surface P-selectin ligand expression.2016

    • Author(s)
      Hiromu Hakematsu, H. kitagawa, R. Kannagi, and S. Oka
    • Organizer
      ICS 2016 (XXVIII Inernatinal Carbohydrate Symposium)
    • Place of Presentation
      New Orieans, Louisiana, USA
    • Year and Date
      2016-07-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Psychosine-triggered endomitosis to produce multiploid cells2016

    • Author(s)
      H. Watanabe, T. Kobayashi, J. Inokuchi, T. Okazaki, S. Oka and H. Takematsu
    • Organizer
      2016 Korea-Japan Bioactive Lipid Joint Symposium
    • Place of Presentation
      BAREVE Hotel in Jeju island, South Korea
    • Year and Date
      2016-05-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2019-03-29  

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