Role of glycans in control of FGF23 and Klotho functions
Project/Area Number |
16K14695
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Functional biochemistry
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Research Institution | Kyoto University |
Principal Investigator |
Oka Shogo 京都大学, 医学研究科, 教授 (60233300)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | αKlotho / FGF23 / HNK-1糖鎖 / 腎臓 / グルクロン酸転移酵素 / 糖鎖 / αKlothoタンパク質 / O型糖鎖 |
Outline of Final Research Achievements |
αKlotho is predominantly expressed in kidney and has important roles in regulation of mineral metabolism including calcium. αKlotho is also known to act as a co-receptor for fibroblast growth factor 23 (FGF23). Mice lacking functional αKlotho protein exhibit phenotypes resembling human aging. α-Klotho is a type I membrane protein with two glucosidase-like domains in a extracellular region. It is, however, still unclear how these glucosidase-like domains are utilized for the klotho function since the essential glutamate residues for enzymatic activity are not conserved in αKlotho. In this study, we investigated the role of HNK-1 and its related glycans in the functional regulation for FGF23 and αKlotho.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts.2017
Author(s)
Nakagawa Y, Nishikimi T, Kuwahara K, Fujishima A, Oka S, Tsutamoto T, Kinoshita H, Nakao K, Cho K, Inazumi H, Okamoto H, Nishida M, Kato T, Fukushima H, Yamashita JK, Wijnen WJ, Creemers EE, Kangawa K, Minamino N, Nakao K, Kimura T.
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Journal Title
J Am Heart Assoc.
Volume: 6
Issue: 2
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Psychosine-triggered endomitosis is modulated by membrane sphingolipids through regulation of phosphoinositide 4,5-bisphosphate production at the cleavage furrow.2016
Author(s)
Watanabe H, Okahara K, Naito-Matsui Y, Abe M, Go S, Inokuchi J, Okazaki T,Kobayashi T, Kozutsumi Y, Oka S, Takematsu H.
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Journal Title
Mol Biol Cell.
Volume: 27
Issue: 13
Pages: 2037-2050
DOI
Related Report
Peer Reviewed / Open Access
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