Signal transduction in cell is only one way?

Research Project

Project/Area Number	16K14710
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Biophysics
Research Institution	Osaka University
Principal Investigator	ISHIJIMA Akihiko 大阪大学, 生命機能研究科, 教授 (80301216)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	バクテリア / 生物物理
Outline of Final Research Achievements	E.coli recognize the environmental stimuli by receptor patch at cell pole and phosphorylate CheA, CheA-P transfer to CheY, CheY-P bind to flagellar motor and rotational direction changed from CCW to CW. In this study, we validate a feedbacksystem of signal transduction system in cell. When the rotation of one motor on the cell was stopped, CWbias of another motor on the same cell was gradually increased. This result suggested that the stopped motor activated the CheA and increased the CWbias of other motor on the same cell.