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Analysis of a novel mechanism by which the orientation of planar cell polarity is reversed

Research Project

Project/Area Number 16K14718
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cell biology
Research InstitutionAkita University

Principal Investigator

YAMAZAKI Masakazu  秋田大学, 医学(系)研究科(研究院), 准教授 (40373378)

Co-Investigator(Kenkyū-buntansha) 秋山 正和  北海道大学, 電子科学研究所, 助教 (10583908)
鮎川 友紀  秋田大学, 医学(系)研究科(研究院), 助教 (80586165)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords発生・分化 / 細胞・組織 / 平面内細胞極性 / PCP / 数理モデル
Outline of Final Research Achievements

Planar cell polarity (PCP) is the collective alignment of polarized cells within the plane of the epithelium. In the Drosophila notum, the sensory bristles consistently point from anterior to posterior, and a defect in the PCP pathway on the notum leads to misoriented bristles. We previously carried out a genome-wide RNAi screen using the Drosophila notum and identified novel genes involved in multiple developmental processes including PCP. One PCP gene we identified in the RNAi screen is jitterbug (jbug), which is the Drosophila filamin ortholog. While RNAi of jbug results in misaligned bristles on the notum like that of known PCP genes, double RNAi of jbug and a member of the PCP core genes displays a unique phenotype in which the orientation of bristles and trichomes is reversed. In this study, using a combination of experiment and theory, we found that external forces generated by the indirect flight muscles play a critical role in the reversed PCP phenotype.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 2016 Other

All Presentation (9 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Remarks (2 results)

  • [Presentation] 平面内細胞極性を司る新規調節機構の解析2018

    • Author(s)
      鮎川友紀,八月朔日泰和,山崎正和
    • Organizer
      第123回 日本解剖学会総会・全国学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 平面内細胞極性を司る新規調節機構の解析2017

    • Author(s)
      鮎川友紀、山崎正和
    • Organizer
      第122回 日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎大学(長崎)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 外力によるPCP制御機構の解析2017

    • Author(s)
      山崎正和
    • Organizer
      第3回 生体調節研究所 内分泌代謝シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 平面内細胞極性を司る新規調節機構の解析2017

    • Author(s)
      鮎川友紀,八月朔日泰和,山崎正和
    • Organizer
      日本解剖学会 第63回東北・北海道連合支部学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 平面内細胞極性の向きが逆転する現象の解析2017

    • Author(s)
      山崎正和
    • Organizer
      第16回 生命科学研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Functional analysis of a PCP regulator Jitterbug2017

    • Author(s)
      Tomonori Ayukawa, Yasukazu Hozumi and Masakazu Yamazaki
    • Organizer
      The 4th Asia-Pacific Drosophila Research Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 平面内細胞極性を司る新規調節機構の解析2016

    • Author(s)
      鮎川友紀、佐々木雄彦、山崎正和
    • Organizer
      第39回 日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] 細胞集団が同じ方向を向く仕組み2016

    • Author(s)
      山崎正和、秋山正和
    • Organizer
      CREST「生命動態の理解と制御のための基盤技術の創出」研究領域 第7回数理デザイン道場
    • Place of Presentation
      日本科学未来館 未来館ホール(東京)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 平面内細胞極性の分子機構 ― 細胞集団が同じ方向に向く仕組み ―2016

    • Author(s)
      山崎正和
    • Organizer
      第115回「細胞シグナリング」研究会
    • Place of Presentation
      横浜市立大学(横浜)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Remarks] 秋田大学大学院医学系研究科 細胞生物学講座

    • URL

      http://www.med.akita-u.ac.jp/department/gs/kenkyu-org/kouza.php?koza=kaibo2

    • Related Report
      2017 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.akita-u.ac.jp/department/gs/kenkyu-org/kouza.php?koza=kaibo2

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2022-12-28  

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