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Water volume regulation involved in primaly blood production

Research Project

Project/Area Number 16K14739
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Developmental biology
Research InstitutionKyushu University

Principal Investigator

Sato Yuki  九州大学, 医学研究院, 准教授 (90508186)

Research Collaborator SHIGEMATSU mugiho  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsアクアポリン / 血管内皮細胞 / 内皮ー造血転換 / 二次造血 / 血球分化 / 造血 / 発生・分化 / 血液 / 血管
Outline of Final Research Achievements

Vascular endothelial cells and blood cells differentiate from common progenitor cells. Both are spatially separated, and blood cells circulate in the blood vessels as the heart starts to beat. Although the molecules involved in the blood and blood vessel differentiation have been detailed, how and when the water of the first appearing blood is taken into the vasculature have not been addressed. In this study, we focused on the water channel molecule Aquaporin1 (AQP1) and analyzed it in order to elucidate the inflow mechanism of water into the blood vessels at the early embryonic development. We found a new possible mechanism by which AQP1-mdeiated selective water influx promotes morphological transition from flat endothelial cells to spherical blood cells.

Academic Significance and Societal Importance of the Research Achievements

内皮ー造血転換の際に観察される扁平(内皮)から球形(血球)の細胞形態変化が一体どのようなしくみによって引き起こされるのかは、これまで未解明であった。本研究から、水チャネルAQPを介しておこる細胞内水流入が細胞の球状化に関わることが明らかになった。水分子の流入制御の観点から血液産生メカニズムを解明しようとした研究はこれまでになく、内皮ー造血転換の分子機構解明に向けて新たな突破口となることが期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2018 2017 Other

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Remarks (2 results)

  • [Journal Article] Androgen Regulates Dimorphic F-Actin Assemblies in the Genital Organogenesis2017

    • Author(s)
      Liu Liqing、Suzuki Kentaro、Chun Eunice、Murashima Aki、Sato Yuki、Nakagata Naomi、Fujimori Toshihiko、Yonemura Shigenobu、He Wanzhong、Yamada Gen
    • Journal Title

      Sexual Development

      Volume: 11 Issue: 4 Pages: 190-202

    • DOI

      10.1159/000477452

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Basal filopodia and vascular mechanical stress organize fibronectin into pillars bridging the mesoderm-endoderm gap2017

    • Author(s)
      Sato Y, Nagatoshi K, Hamano A, Imamura Y, Huss D, Uchida T, Lansford R
    • Journal Title

      Development

      Volume: 144 Issue: 2 Pages: 281-291

    • DOI

      10.1242/dev.141259

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Cell Budding During Endothelial to Hematopoietic Transition is Regulated by Aquaporin Water Channels2018

    • Author(s)
      Mugiho Shigematsu, Chie Tamura, Yuki Sato
    • Organizer
      KEY forum
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cell Budding During Endothelial to Hematopoietic Transition is Regulated by Aquaporin Water Channels2018

    • Author(s)
      Mugiho Shigematsu, Chie Tamura, Yuki Sato
    • Organizer
      Joint Annual Meeting of JSDB 51st and JSCB 70th
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脈動による空間伸縮が形態形成に果たす役割2017

    • Author(s)
      佐藤 有紀
    • Organizer
      Conbio 2017
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Cell Budding During Endothelial to Hematopoietic Transition is Regulated by Aquaporin Water Channels2017

    • Author(s)
      Mugiho Shigematsu, Chie Tamura, Yuki Sato
    • Organizer
      KEY forum
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Remarks] 九州大学研究者情報

    • URL

      http://hyoka.ofc.kyushu-u.ac.jp/search/details/K005416/index.html

    • Related Report
      2016 Research-status Report
  • [Remarks] プレスリリース

    • URL

      http://yomiuri-techno.jp/sangyo/20170118_1.pdf

    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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