Germ cell-intrinsic function of sex chromosome in oogenesis
| Project/Area Number |
16K14740
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Developmental biology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 卵母細胞 / 性染色体 / 減数分裂 / 性差 / 始原生殖細胞 / 配偶子形成 / 性分化 |
|---|
| Outline of Final Research Achievements |
This study is aimed at understanding molecular mechanisms of sex chromosomes on oogenesis. Using an oocyte differentiation system, oocytes were produced from embryonic stem (ES) cells harboring XX, XY or XO chromosomes. The number of oocytes from XY and XO ES cells was much fewer than those from XX ES cells. Detail analyses demonstrated that the reasons of attenuated oocyte production from XO and XY ES cells were (1) mispairing of the sex chromosome during meiotic prophase I, (2) lower dosage of X chromosome, (3) a negative impact of a gene on Y chromosome. We identified a novel function of the Y-linked gene on meiotic progression. These results contribute to understanding of reasons why oocyte production is attenuated in patients with sex chromosome disorder.
|
Report
(3 results)
Research Products
(32 results)
-
-
-
[Journal Article] Reconstitution in vitro of the entire cycle of the mouse female germ line.2016
Author(s)
Hikabe O, Hamazaki N, Nagamatsu G, Obata Y, Hirao Y, Hamada N, Shimamoto S, Imamura T, Nakashima K, Saitou M, Hayashi K
-
Journal Title
Nature
Volume: 539
Issue: 7628
Pages: 299-303
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
[Journal Article] Rewinding the process of mammalian extinction.2016
Author(s)
Saragusty J, Diecke S, Drukker M, Durrant B, Friedrich B-N I, Galli C, Göritz F, Hayashi K, Hermes R, Holtze S, Johnson S, Lazzari G, Loi P, Loring JF, Okita K, Renfree MB, Seet S, Voracek T, Stejskal J, Ryder OA, Hildebrandt TB.
-
Journal Title
Zoo Biol.
Volume: 35
Issue: 4
Pages: 280-292
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
