Research Project
Grant-in-Aid for Challenging Exploratory Research
This study is aimed at understanding molecular mechanisms of sex chromosomes on oogenesis. Using an oocyte differentiation system, oocytes were produced from embryonic stem (ES) cells harboring XX, XY or XO chromosomes. The number of oocytes from XY and XO ES cells was much fewer than those from XX ES cells. Detail analyses demonstrated that the reasons of attenuated oocyte production from XO and XY ES cells were (1) mispairing of the sex chromosome during meiotic prophase I, (2) lower dosage of X chromosome, (3) a negative impact of a gene on Y chromosome. We identified a novel function of the Y-linked gene on meiotic progression. These results contribute to understanding of reasons why oocyte production is attenuated in patients with sex chromosome disorder.
All 2018 2017 2016
All Journal Article (7 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 6 results, Open Access: 6 results, Acknowledgement Compliant: 2 results) Presentation (24 results) (of which Int'l Joint Research: 11 results, Invited: 24 results) Patent(Industrial Property Rights) (1 results)
The EMBO Journal
Volume: 36 Issue: 21 Pages: 3100-3119
10.15252/embj.201796875
Nature Protocols
Volume: 12 Issue: 9 Pages: 1733-1744
10.1038/nprot.2017.070
Nature
Volume: 539 Issue: 7628 Pages: 299-303
10.1038/nature20104
Protocol Exchange.
Volume: -
Dev Cell.
Volume: 39 Pages: 87-103
Proc Natl Acad Sci USA
Volume: 113 Pages: 9021-9026
Zoo Biol.
Volume: 35 Issue: 4 Pages: 280-292
10.1002/zoo.21284
