| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Outline of Final Research Achievements |
By using nuclear transfer method, totipotent cells, which can be developed into all types of tissues including placenta. In contrast, ES cells and iPS cells can be developed into many types of tissue, but they cannot be developed into placenta. We compared the gene expression patterns between ES cells and the 4-cell embryos, which have the capacity to develop into all types of tissues, and selected some genes of which expression levels is higher in the 4-cell embryos. ES cells expressing higher level of those specific genes had higher efficiency to differentiate into both embryonic and extra-embryonic tissues. Thus, results of this study may contribute to the generation of totipotent cells from somatic cells,
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