Research Project
Grant-in-Aid for Challenging Exploratory Research
The purpose of this study is to clarify novel regulatory mechanisms of nuclear gene expression regulated by chloroplast-to nucleus retrograde (plastid) signals. We found that GUN1, one of the central regulators, accumulates and functions during very early stage of plant development, and that nuclear gene expression could be regulated by the epigenetic control such as histone modification. Furthermore, roles of plastid signals in light- and circadian clock-dependent gene expression, as well as similar stress response mechanisms in photosynthetic microorganisms, have been also characterized.
プラスチドシグナル伝達については、国内外の多くの研究者から注目が集まっており、これに関する国際シンポジウムが頻繁に開かれるほどホットな分野である。本研究により、その新しい分子機構や生理応答の側面を明らかにできたことで、植物分子細胞生物学分野の発展に大きく寄与できたものと考えられる。また、植物の光合成や代謝機能は、プラスチドシグナルも深く関わる核ゲノムと葉緑体ゲノムの遺伝子発現協調を前提としているので、様々な環境下に適応できる新たな作物の開発など、応用研究に向けての分子基盤としても強く期待される。
All 2019 2018 2017 2016
All Journal Article (3 results) (of which Peer Reviewed: 3 results, Open Access: 3 results) Presentation (15 results) (of which Int'l Joint Research: 3 results, Invited: 2 results) Book (1 results)
Food Science and Nutrition
Volume: 7 Issue: 4 Pages: 1494-1501
10.1002/fsn3.993
Nucleic Acids Research
Volume: 45 Issue: D1 Pages: 551-554
10.1093/nar/gkw1131
Plant Cell Physiol.
Volume: in press Issue: 5 Pages: 953-960
10.1093/pcp/pcw054
