| Project/Area Number |
16K14788
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Evolutionary biology
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| Research Institution | Kyoto Prefectural University |
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Principal Investigator |
Matsuo Mitsuhiro 京都府立大学, 生命環境科学研究科, 特任助教 (70415298)
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| Co-Investigator(Kenkyū-buntansha) |
小保方 潤一 京都府立大学, 生命環境科学研究科, 教授 (50185667)
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| Co-Investigator(Renkei-kenkyūsha) |
Murakami Akio 神戸大学, 内海域環境教育研究センター, 准教授 (50304134)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 一次細胞内共生進化 / エピトランスクリプトーム / RNAシュードウリジン化 / 有殻アメーバ / シアネレ / 細胞内共生進化 / 葉緑体 / RNA修飾 |
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| Outline of Final Research Achievements |
Epitranscriptome means all the biochemical modifications of the RNA within a cell. Increasing evidence suggests that epitranscriptomic diversity makes a new layer of controlling the genomic functions in addition to the classical gene regulatory steps and epigenomic diversity. Our preliminary genome analysis of a photosynthetic amoeba, Paulinella micropora, suggests that the enzymes involved in RNA modification should be preferentially acquired by horizontally- and endosymbiotically-gene transfer at the early stage of the primary endosymbiotic evolution. To gain insight for the relationship between RNA modification and endosymbiotic evolution, we performed the comprehensive analysis of RNA pseudouridylation, one of major RNA modifications, in P. micropora. Our analysis detected the novel RNA pseudouridylations in the photosynthetic organelle of this organism, suggesting that the organelle epitranscriptome might be altered in the primary endosymbiotic evolution.
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