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Evolutionary game in the social amoeba: Quantification of evolutionary dynamics among interacting diverse cell lineages

Research Project

Project/Area Number 16K14805
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Ecology/Environment
Research InstitutionThe University of Tokyo

Principal Investigator

SHIMADA Masakazu  東京大学, 大学院総合文化研究科, 名誉教授 (40178950)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords細胞性粘菌 / 協力行動 / 進化動態 / 細胞系譜 / 社会分業 / 社会形成 / 裏切り行動 / 進化ゲーム / 分業 / DNAバーコード / 裏切りと協力の細胞ダイナミクス / DNAバーコーディング / 細胞系譜の遺伝系図 / 数理モデル
Outline of Final Research Achievements

We investigate maintenance of cooperation using a social amoeba Dictyostelium descoideum. We focused on social loss under environments where fitness as a solitary individual surpasses that as a social group member. From live-cell imaging, we revealed that cells that switch back to the solitary state were disadvantageous, because they were forced to take an altruistic role when allowed to interact with social cells. The results indicate that division of labor process of the social amoeba will contribute to maintaining cooperation even under environments where solitary cells are advantageous. Furthermore, to measure evolutionary dynamics under the prevention of social loss, populations with random mutations were constructed, and nucleotide sequences of the mutants were decided with next-generation sequencer. We are in the trial and error stage to find an effective way to measure each mutant number, and have some good prospect on quantitative measurement of the evolutionary dynamics.

Academic Significance and Societal Importance of the Research Achievements

生物が複雑な社会性を進化させるためには、安定して協力を継続する必要がある。しかし協力の継続は、いくつかの要因で阻害されうる。一つは協力を搾取する裏切り行動の侵入である。もう一つは環境変動で協力よりも単独行動が有利となれば協力はあっさり失われるだろう。これまで前者に対しては、多くの解決策が見出されてきた。しかし後者は説明が難しく国内外でも研究例が少ない。本研究は、細胞性粘菌が既に持っている社会分業体制が、副産物として単独行動が有利な環境でも協力を維持するのに役立つことを世界に先駆けて示している。さらにこの独自の実験系を用い、進化動態を実測する手法を開発途上にあり、今後さらなる発展が見込まれる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (20 results)

All 2020 2019 2018 2017 2016 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Remarks (4 results)

  • [Journal Article] Cyclic dominance emerges from the evolution of two inter-linked cooperative behaviours in the social amoeba2018

    • Author(s)
      Shibasaki Shota、Shimada Masakazu
    • Journal Title

      Proceedings of the Royal Society B: Biological Sciences

      Volume: 285 Issue: 1881 Pages: 20180905-20180905

    • DOI

      10.1098/rspb.2018.0905

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cyclic dominance emerges from the evolution of two cooperative behaviors in the social amoeba2018

    • Author(s)
      Shibasaki Shota、Shimada Masakazu
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/251553

    • Related Report
      2017 Research-status Report
    • Open Access
  • [Journal Article] Stochastic sexual interaction facilitates the evolution of asexual cooperation in the social amoeba2017

    • Author(s)
      Shibasaki Shota、Shimada Masakazu
    • Journal Title

      Proceedings of European Conference on Artificial Life

      Volume: 14 Pages: 372-379

    • DOI

      10.7551/ecal_a_064

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cooperation Induces Other Cooperation: Fruiting Bodies Promotes the Evolution of Macrocysts in Dictyostelium discoideum2017

    • Author(s)
      Shibasaki S., Shirokawa Y., Shimada M.
    • Journal Title

      Journal of Theoretical Biology

      Volume: 421 Pages: 136-145

    • DOI

      10.1016/j.jtbi.2017.04.002

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cytoplasmic inheritance of parent-offspring cell structure in the clonal diatom Cyclotella meneghiniana2016

    • Author(s)
      Shirokawa Y., Shimada M.
    • Journal Title

      Proceedings of the Royal Society B Biological Sciences

      Volume: 283 Issue: 1842 Pages: 20161632-20161632

    • DOI

      10.1098/rspb.2016.1632

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Cell fate determination in the social amoeba Dictyostelium discoideum penalizes precocious reversion to solitary growth2020

    • Author(s)
      Y. Shirokawa, M. Shimada, N. Shimada, S. Sawai.
    • Organizer
      Discussion Meeting on Conflict and Cooperation in Cellular Populations (CCCP 2020)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 微生物の競争と協力がもたらす帰結: 細胞性粘菌と中心珪藻を例として2020

    • Author(s)
      城川祐香
    • Organizer
      産業技術総合研究所公開セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Evolutionary stability of cooperation against selection for solitary proliferation in the social amoeba2019

    • Author(s)
      城川祐香、嶋田正和、澤井哲
    • Organizer
      第66回日本生態学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Cyclic dominance emerges from the two cooperative behaviors in the social amoeba.2018

    • Author(s)
      S. Shibasaki and M. Shimad
    • Organizer
      ゲーム理論ワークショップ2018
    • Related Report
      2017 Research-status Report
  • [Presentation] 社会を去るときは協力者になってから~細胞性粘菌の脱分化の進化生態学2017

    • Author(s)
      城川祐香、嶋田正和、澤井哲
    • Organizer
      第64回日本生態学会大会
    • Place of Presentation
      早稲田大学(東京都新宿区)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
  • [Presentation] Evolution of cooperation with the multi-game dynamics in the social amoeba.2017

    • Author(s)
      S. Shibasaki and M. Shimada
    • Organizer
      第27回日本数理生物学会年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Irreversibility of social organization arises from cooperation cost in the social amoeba2017

    • Author(s)
      Y. Shirokawa, M. Shimada, S. Sawai
    • Organizer
      個体群生態学会第33回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Stochastic sexual interaction facilitates the evolution of asexual cooperation in the social amoeba.2017

    • Author(s)
      S. Shibasaki and M. Shimada
    • Organizer
      European Conference on Artificial Life
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The evolutionary game in sexual reproduction of the social amoeba2016

    • Author(s)
      Shibasaki S., Shirokawa Y., Shimada M.
    • Organizer
      The 2016 (26th) annual meeting of the Japanese Society for Mathematical Biology
    • Place of Presentation
      九州大学(福岡県福岡市)
    • Year and Date
      2016-09-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 細胞性粘菌 Dictyostelium discoideum の有性生殖における協力と裏切り2016

    • Author(s)
      柴﨑祥太、城川祐香、嶋田正和
    • Organizer
      日本新化学会第18回大会
    • Place of Presentation
      東京工業大学(東京都目黒区)
    • Year and Date
      2016-08-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Evolutionary ecology on cellular heterogeneity: cell competition, cooperation and evolution2016

    • Author(s)
      Yuka Shirokawa
    • Organizer
      Department of Evolutionary Studies of Biosystems Seminars
    • Place of Presentation
      総合研究大学院大学(神奈川県葉山町)
    • Year and Date
      2016-06-21
    • Related Report
      2016 Research-status Report
    • Invited
  • [Remarks]

    • URL

      https://sites.google.com/view/shimada-lab/publications

    • Related Report
      2019 Annual Research Report
  • [Remarks] MASAKAZU SHIMADA'S HOMEPAGE

    • URL

      https://sites.google.com/view/shimada-lab/publications

    • Related Report
      2018 Research-status Report
  • [Remarks] 東京大学大学院総合文化研究科嶋田研究室ホームページ

    • URL

      http://park.itc.u-tokyo.ac.jp/shimada-lab/activities.html

    • Related Report
      2017 Research-status Report
  • [Remarks] 東京大学大学院総合文化研究科嶋田研究室ホームページ

    • URL

      http://park.itc.u-tokyo.ac.jp/shimada-lab/index.html

    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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