Foundation and application of Cordyceps - Elucidation of fungal infection mechanism and exploration of functional substances
| Project/Area Number |
16K14912
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Shizuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
道羅 英夫 静岡大学, 理学部, 准教授 (10311705)
河岸 洋和 静岡大学, グリーン科学技術研究所, 教授 (70183283)
朴 龍洙 静岡大学, グリーン科学技術研究所, 教授 (90238246)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Cordyceps / ゲノム解析 / 機能性物質 / 交配型遺伝子 / サナギタケ / ゲノムシーケンス / 交配型 / 代謝産物 / 冬虫夏草 |
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| Outline of Final Research Achievements |
Cordyceps is an ascomycete that is parasitic on lepidopteran insects and its fruit body is useful as a traditional Chinese medicine, but its molecular mechanism of infection and fruit body formation has many unclear points. It was revealed that a part of the MAT chromosome underwent recombination with other chromosomes in C. militaris, suggesting that the chromosome is unstable. In addition, it was revealed that the expression levels of gene clusters involved in cordycepin production differ between mating types. In addition, we succeeded in isolation of compounds showing toxicity against cancer cells.
Thus, in this study, we improved genome information useful for elucidation of biological phenomena such as infestation of C. militaris and the formation of fruiting bodies, and succeeded in isolation of functional substances.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Cytotoxic compounds against cancer cells from Bombyx mori inoculated with Cordyceps militaris2017
Author(s)
1.Qiu, W., Wu, J., Choi, J.-H., Hira, H., Nishida, H., and Kawagishi, H.
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Journal Title
Biosci. Biotechnol. Biochem.
Volume: 印刷中
Issue: 6
Pages: 1224-1226
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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