| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Secondary metabolite production in Streptomyces is strictly controlled by signaling moleclues. We analyzed structural diversity, biosynthesis and biological activity of the signaling molecules SRBs that induce antibiotic production in Streptomyces rochei. The followings are short summary in this project.
(1) Around 80 Streptomyces strains showed no ability to induce antibiotic production in S. rochei, suggesting their signaling molecules are different from SRB-type molecules. (2) P450 monooxygenase SrrO is responsible to oxidize C-6’ methylene group during SRB biosynthesis. (3) Exogenous addition of SRBs caused alteration of the metabolic profiles among some Streptomyces strains.
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