Collective activation of silent biosynthetic pathways for bioactive compounds by small diffusible signaling molecules
| Project/Area Number |
16K14915
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
ARAKAWA Kenji 広島大学, 先端物質科学研究科, 准教授 (80346527)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | シグナル分子 / 二次代謝生合成 / 放線菌 / ゲノムマイニング / P450 / デヒドロゲナーゼ / ブテノライド |
|---|
| Outline of Final Research Achievements |
Secondary metabolite production in Streptomyces is strictly controlled by signaling moleclues. We analyzed structural diversity, biosynthesis and biological activity of the signaling molecules SRBs that induce antibiotic production in Streptomyces rochei. The followings are short summary in this project.
(1) Around 80 Streptomyces strains showed no ability to induce antibiotic production in S. rochei, suggesting their signaling molecules are different from SRB-type molecules. (2) P450 monooxygenase SrrO is responsible to oxidize C-6’ methylene group during SRB biosynthesis. (3) Exogenous addition of SRBs caused alteration of the metabolic profiles among some Streptomyces strains.
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Report
(3 results)
Research Products
(69 results)
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[Journal Article] Molecular characterization of aspartylglucosaminidase, a lysosomal hydrolase upregulated during strobilation in the moon jellyfish, Aurelia aurita.2017
Author(s)
Tsujita,N., Kuwahara,H., Koyama,H., Yanaka,N., Arakawa,K., Kuniyoshi,H.
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 81
Issue: 5
Pages: 938-950
DOI
Related Report
Peer Reviewed
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[Journal Article] Antitumor activity of lankacidin antibiotics is due to microtubule stabilization via a paclitaxel-like mechanism2016
Author(s)
Ahmed Taha Ayoub, Rabab Ahmed, Jack Xiao, Cody Wayne Lewis, Tatiana Tilli, Kenji Arakawa, Yosi Nindita, Gordon Chan, Luxin Sun, Mark Glover, Mariusz Klobukowski, Jack Tuszynski
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Journal Title
J. Med. Chem.
Volume: 59
Issue: 20
Pages: 9532-9540
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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