Identification of molecules that increase in response to bile acid supplementation and Involvement of those in life style-related diseases
Project/Area Number |
16K14917
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Food science
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Research Institution | Hokkaido University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
清水 英寿 島根大学, 生物資源科学部, 准教授 (10547532)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 胆汁酸 |
Outline of Final Research Achievements |
Excess energy intake during aging enhances bile acid secretion from liver to intestinal lumen. Several symptoms are developed by the diet supplemented with cholic acid to mimic that condition accompanied by alteration of bile acid metabolism in organs and blood. We investigated bile acid metabolism to find responsible molecular species of bile acid for development of the symptoms observed in the cholic acid supplementation. Consequently, the cholic acid supplementation is involved in lipid accumulation via modulation of sterol metabolism by increase mainly in deoxycholic acid and taurocholic acid.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Combination of soya pulp and Bacillus coagulans lilac-01 improves intestinal bile acid metabolism without impairing the effects of prebiotics in rats fed a cholic acid-supplemented diet.2016
Author(s)
Lee Y, Yoshitsugu R, Kikuchi K, Joe GH, Tsuji M, Nose T, Shimizu H, Hara H, Minamida K, Miwa K, Ishizuka S.
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Journal Title
British Journal of Nutrition
Volume: 116
Issue: 4
Pages: 603-610
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Ingestion of skim milk cheese modulates bile acid metabolism and cholic acid-induced disorders in rats.2017
Author(s)
Lee DG, Takahashi Y, Shimoda T, Lee Y, Joe GH, Kamo Y, Hori S, Hanai T, Takeuchi A, Tanaka Y, Shimizu H, Kumura H, Ishizuka S.
Organizer
The International Conference of Korean Society of Food Science of Animal Resources and 49th Annual Meeting
Related Report
Int'l Joint Research
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