Study on sensing mechanism of low-digestible saccharides in nutrient-sensing enteroendocrine cells
| Project/Area Number |
16K14918
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Hokkaido University |
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Principal Investigator |
Hara Hiroshi 北海道大学, 農学研究院, 教授 (70198894)
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| Co-Investigator(Kenkyū-buntansha) |
比良 徹 北海道大学, 農学研究院, 講師 (10396301)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 難消化性糖質 / GLP-1 / アルロース / 難消化性デキストリン / GIP / 栄養センサー / 消化管内分泌細胞 |
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| Outline of Final Research Achievements |
We examined the effects of indigestible saccharides including rare sugar D-allulose on a gut hormone GLP-1 secretion. Single oral administration of resistant maltodextrin (RMD) or D-allulose potently stimulated GLP-1 secretion in rats. D-allulose had larger and continuous stimulatory effect on GLP-1 secretion than RMD. The GLP-1-stimulating effect was observed by oral and luminal but not by intraperitoneal administration of D-allulose, indicating D-allulose exerted the effect in the intestinal lumen. These results demonstrate important role of enteroendocrine cell to sense indigestible saccharides in gut hormone secretions under a physiological condition.
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Report
(3 results)
Research Products
(5 results)
