The preventive effects of lutein and catechin on locomotive syndrome.
| Project/Area Number |
16K14921
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
MIYAURA CHISATO 東京農工大学, 工学(系)研究科(研究院), 教授 (20138382)
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| Co-Investigator(Kenkyū-buntansha) |
平田 美智子 東京農工大学, 工学(系)研究科(研究院), 講師 (40544060)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ロコモティブシンドローム / ロコモティブシンドローム予防 / 食品機能 |
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| Outline of Final Research Achievements |
The aim of this study is the usage of food-derived components to prevent the locomotive syndrome (LOCOMO: Motor instrument syndrome) in middle-aged and aged persons. LOCOMO is caused by the decrease in motor function, aging, bone loss and muscle atrophy. Using tail suspension mice, the bone density was measured by DEXA, and the bone and muscle morphology were measured by three-dimensional micro-CT. We established the LOCOMO model to evaluate motor function using a live mouse. Using the LOCOMO model, we found that lutein recover the bone loss induced by tail suspension. Lutein was applied for mass identification using imaging mass spectrometry (iMS), and we identified the lutein molecule and its imaging. Our data may be useful for the development of functional foods using lutein to prevent LOCOMO.
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Report
(3 results)
Research Products
(43 results)
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[Journal Article] Raloxifene reduces the risk of local alveolar bone destruction in a mouse model of periodontitis combined with systemic postmenopausal osteoporosis.2018
Author(s)
Ichimaru R, Tominari T, Yoshinouchi S, Matsumoto C, Watanabe K, Hirata M, Numabe Y, Murphy G, Nagase H, Miyaura C, Inada M
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Journal Title
Arch. Oral Biol.
Volume: 85
Pages: 98-103
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Effects of O-methylated (－)-epigallocatechin gallate (EGCG) on LPS-induced osteoclastogenesis, bone resorption, and alveolar bone loss in mice.2017
Author(s)
Tominari T, Ichimaru R, Yoshinouchi S, Matsumoto C, Watanabe K, Hirata M, Grundler FM, Inada M, Miyaura C
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Journal Title
FEBS Open Bio.
Volume: 7
Pages: 1972-1981
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Indoxyl sulfate, a uremic toxin in chronic kidney disease, suppresses both bone formation and bone resorption.2017
Author(s)
Watanabe K, Tominari T, Hirata M, Matsumoto C, Hirata J, Murphy G, Nagase H, Miyaura C, Inada M
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Journal Title
FEBS Open Bio.
Volume: 7
Pages: 1178-1185
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] BA321, a novel carborane analog that binds to androgen and estrogen receptors, acts as a new selective androgen receptor modulator of bone in male mice.2016
Author(s)
Watanabe K, Hirata M, Tominari T, Matsumoto C, Endo Y, Murphy G, Nagase H, Inada M, Miyaura C
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 478(1)
Pages: 279-285
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The optimal duration of PTH(1-34) infusion is one hour per day to increase bone mass in rats.2016
Author(s)
Shimizu M, Noda H, Joyashiki E, Nakagawa C, Asanuma K, Hayasaka A, Kato M, Nanami M, Inada M, Miyaura C, Tamura T
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Journal Title
Biol Pharm Bull.
Volume: 39(4)
Pages: 625-630
Related Report
Peer Reviewed / Open Access
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