| Project/Area Number |
16K14925
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Research Collaborator |
Montminy Marc Salk Institute, Professor
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 糖尿病 / 高脂肪食 / 転写因子 / 生理学 / 病理学 / 栄養学 |
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| Outline of Final Research Achievements |
We studied the induction mechanism of diabetes in CRTC1 knockout mouse. We found that High fat diet (HFD) induced severe hyperglycemia, hyperinsulinemia and insulin resistance in CRTC1KO mice. Furthermore, HFD elicited fatty liver, lipodystrophy and inflammation in visceral adipose tissue in CRTC1 KO mice. Tranplantation of adipose tissue from Wild type animal into CRTC1 KO mice successfully cured diabetes. These results indicate that HFD may activate CRTC1 in adipose tissue, suppressing inflammation. Also, CRTC1 may regulate gene expression related to glucose homeostasis.
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