Constitutive and structural changes of membrane microdomains and lipid accumulation control by food chemicals
| Project/Area Number |
16K14928
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
加藤 陽二 兵庫県立大学, 環境人間学部, 教授 (30305693)
中村 俊之 岡山大学, 環境生命科学研究科, 助教 (90706988)
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| Research Collaborator |
LIU Xiaoyang
YANG Qifu
LIANG Ying
SASAKI Ikumi
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 食品 / 生体分子 / 分析化学 / 生化学 / 膜マイクロドメイン / インスリン / イソチオシアネート |
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| Outline of Final Research Achievements |
The purpose of this study was to clarify the physiological significance of the constitutive and structural changes of membrane microdomains by food chemicals through studies on their modulation of insulin signaling activation and its consequent phenomena such as the cancer cell survival and lipid accumulation. We identified benzyl isothiocyanate (BITC) as an insulin signal modulator. BITC enhanced glucose uptake in adipocytes as well as the survival pathway and autophagy in colorectal cancer cells, possibly through the activation of insulin signaling. The anti-cancer effect of BITC was potentiated by insulin signaling inhibitors as well as methyl-β-cyclodextrin, a depleting agent of membrane cholesterol.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] 3,4-Dihydroxyphenylacetic acid is a predominant biologically-active catabolite of quercetin glycosides.2016
Author(s)
Tang, Y., Nakashima, S., Saiki, S., Myoi, Y., Abe, N., Kuwazuru, S., Zhu, B., Ashida, H., Murata, Y., Nakamura, Y.
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Journal Title
Food Res. Int.
Volume: 89
Pages: 716-723
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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