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Comprehensive analysis by 'Immunobiogenomics' for expanding the immunobiotic availability

Research Project

Project/Area Number 16K15028
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Animal production science
Research InstitutionTohoku University

Principal Investigator

Kitazawa Haruki  東北大学, 農学研究科, 准教授 (10204885)

Co-Investigator(Kenkyū-buntansha) 麻生 久  東北大学, 農学研究科, 教授 (50241625)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords畜産学 / イムノバイオティクス / 免疫学 / イムノバイオゲノミクス / トランスクリプトミクス / 食品 / 飼料 / 微生物 / 食品・飼料 / 動物
Outline of Final Research Achievements

In this study, we were able to build a certain base for elucidating a strain-specific mucosal immunoregulatory mechanisms of Immunobiotics by constructing an "Immunobiogenomics" in the interdisciplinary study field between bioinformatics and immunobiotics. Expansion for effective availability of Immunobiotics is expected and can thereby contribute to further studies and industrial development.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (20 results)

All 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (10 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 10 results,  Open Access: 9 results,  Acknowledgement Compliant: 5 results) Presentation (6 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Int'l Joint Research] CERELA-CONICET(Argentina)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] CERELA-CONICET(Argentina)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Immunobiotics for the bovine host: their interaction with intestinal epithelial cells and their effect on antiviral immunity.2018

    • Author(s)
      Julio Villena, Hisashi Aso, Victor P. Rutten, Hideki Takahashi, Willem Van Eden and Haruki Kitazawa
    • Journal Title

      Frontiers in Immunology

      Volume: 9 Pages: 326-326

    • DOI

      10.3389/fimmu.2018.00326

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exopolysaccharides from Lactobacillus delbrueckii OLL1073R-1 modulate innate antiviral immune response in porcine intestinal epithelial cells2017

    • Author(s)
      Paulraj Kanmani, Leonardo Albarra2018.00326in, Hisakazu Kobayashi, Hikaru Iida, Ryoya Komatsu, A.K.M. Humayun Kober, Wakako Ikeda-Ohtsubo, Yoshihito Suda, Hisashi Aso, Seiya Makino, Hiroshi Kano, Tadao Saito, JulioVillen, Haruki Kitazawa
    • Journal Title

      Molecular Immunology

      Volume: 93 Pages: 253-265

    • DOI

      10.1016/j.molimm.2017.07.009

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Peptidoglycan from immunobiotic Lactobacillus rhamnosus improves resistance of infant mice to respiratory syncytial viral infection and secondary pneumococcal pneumonia.2017

    • Author(s)
      Clua, P., P. Kanmani, H. Zelaya, A. Tada, AKM H. Kober, S. Salva, S. Alvarez, H. Kitazawa, J. Villena
    • Journal Title

      Front. Immunol.

      Volume: 8(948) Pages: 1-15

    • DOI

      10.3389/fimmu.2017.00948

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Draft genome sequence of immunobiotic Lactobacillus rhamnosus IBL027 a potential adjuvant for mucosal vaccine development.2017

    • Author(s)
      Maria Guadalupe Vizoso-Pinto, M. G., L. Saavedra, E. Hebert, F. R. Tonetti, L. Albarracin, S. Alvarez, H. Kitazawa, J. Villena
    • Journal Title

      Genome Announc.

      Volume: 5(50):e01268-17 Issue: 50 Pages: 1-2

    • DOI

      10.1128/genomea.01268-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transcriptomic analysis of the innate antiviral immune response in porcine intestinal epithelial cells: influence of immunobiotic lactobacilli.2017

    • Author(s)
      Albarracin, L., H. Kobayashi, H. Iida, N. Sato, T. Nochi, H. Aso, S. Salva, S. Alvarez, H. Kitazawa, J. Villena
    • Journal Title

      Front. Immunol.

      Volume: 8(57) Pages: 1-15

    • DOI

      10.3389/fimmu.2017.00057

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Draft genome sequence of Lactobacillus plantarum MPL16 a wakame-utilizing immunobiotic strain from swine feces.2017

    • Author(s)
      Villena, J., L. Saavedra, E. Hebert, Y. Suda, Y. Masumizu, L. Albarracin, P. Clua, W. Ikeda-Ohtsubo, H. Kitazawa
    • Journal Title

      Genome Announc.

      Volume: 5(10): e00006-17 Issue: 10 Pages: 1-2

    • DOI

      10.1128/genomea.00006-17

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Draft genome sequence of the immunobiotic strain Lactobacillus jensenii TL2937.2017

    • Author(s)
      Villena, J.,Y. Masumizu, H. Ida, W. Ikeda-Ohtsubo, L. Albarracin, S. Makino, S. Ohkawara, K.i Kimura, L. Saavedra, E. Hebert, H. Kitazawa
    • Journal Title

      Genome Announc.

      Volume: 5(9): e00005-17 Issue: 9 Pages: 1-2

    • DOI

      10.1128/genomea.00005-17

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Modulation of porcine intestinal epitheliocytes immunetranscriptome response by Lactobacillus jensenii TL2937: finding new biomarkers for the selection of antiinflammatory immunobiotics.2016

    • Author(s)
      Kobayashi, H., L. Albarracin, N. Sato, P. Kanmani, AKM H. Kober, W. Ikeda-Ohtsubo, Y. Suda, T. Nochi, H. Aso, S. Makino, H. Kano, S. Ohkawara, T. Saito, J. Villena, H. Kitazawa
    • Journal Title

      Beneficial Microbes, Benef Microbes

      Volume: 7 Issue: 5 Pages: 769-782

    • DOI

      10.3920/bm2016.0095

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Draft Genome Sequence of Lactobacillus plantarum TL2766, a strain with the ability to ferment wakame.2016

    • Author(s)
      Villena, J., L. Saavedra, E. Hebert, Y. Masumizu, N. Sato, AKM H. Kober, L. Albarracin, W. Ikeda-Ohtsubo, S. Makino, K. Kimura, S. Ohkawara, H. Kitazawa
    • Journal Title

      Genome Announc.

      Volume: 4(6): e01328-16 Issue: 6 Pages: 1-2

    • DOI

      10.1128/genomea.01328-16

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Immunobiotic Lactobacillus strains reduce small intestinal injury induced by intraepithelial lymphocytes after Toll-like receptor 3 activation.2016

    • Author(s)
      Tada, A., H. Zelaya, P. Clua, S. Salva, S. Alvarez, H. Kitazawa, J. Villena
    • Journal Title

      Inflamm. Res.

      Volume: 65(10) Issue: 10 Pages: 771-783

    • DOI

      10.1007/s00011-016-0957-7

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] ブタ腸管由来ワカメ資化性乳酸菌のイムノバイオティック利用性2017

    • Author(s)
      舛水由季、飯田ひかる、須田義人、大坪和香子、麻生 久、齋藤忠夫、鈴木啓一、北澤春樹
    • Organizer
      日本畜産学会第122回大会
    • Place of Presentation
      神戸大学(兵庫県神戸市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Lactobacillus delbrueckii OLL1073R-1由来菌体外多糖のブタ腸管上皮細胞における抗ウイルス自然免疫修飾2017

    • Author(s)
      小松稜弥、須田義人、牧野聖也、狩野 宏、齋藤忠夫、北澤春樹
    • Organizer
      日本食品免疫学会 第13回学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] "Immunosynbiotics" approach by using wakame and immunobiotics as livestock healthy growth strategy2017

    • Author(s)
      Nakano, Y., Y. Masumizu, AKM. H. Kober, V. Garcia, W. Ikeda-Ohtsubo, Y. Suda, K. Suzuki, T. Saito, J. Villena, H. Kitazawa
    • Organizer
      日本畜産学会第123回大会 (英語口頭発表)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 畜産食品の安全性向上に寄与するブタ由来ワカメ資化性乳酸菌のイムノバイオティック利用性2016

    • Author(s)
      舛水由季、飯田ひかる、須田義人、齋藤忠夫、北澤春樹
    • Organizer
      日本食品免疫学会第12回学術大会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2016-11-09
    • Related Report
      2016 Research-status Report
  • [Presentation] Isolation and characterization of Lactobacillus plantarum MPL16: A Wakame-utilizing immunobiotic strain from swine feces.2016

    • Author(s)
      Masumizu, Y., AKM H. Kober, B. Tzu-An Chao, H. Iida, W. Ikeda-Ohtsubo, Y. Suda, L. Albarracin, L. Saavedra, E.M. Hebert, T. Nochi, H. Aso, T. Saito, K. Suzuki, J. Villena, H. Kitazawa
    • Organizer
      V International Symposium on Lactic Acid Bacteria - Benefitting from lactic acid bacteria, Progress in health and food
    • Place of Presentation
      Tucuman, Argentina
    • Year and Date
      2016-10-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ワカメ資化性イムノバイオティクスの応用基礎研究2016

    • Author(s)
      舛水由季、AKM H. Kober、B. Tzu-An Chao、飯田ひかる、大坪和香子、須田義人、麻生 久、齋藤忠夫、鈴木啓一、J. Villena、北澤春樹
    • Organizer
      2016年度酪農科学シンポジウム
    • Place of Presentation
      日本大学生物資源科学部(神奈川藤沢市)
    • Related Report
      2016 Research-status Report
  • [Remarks] 食と農免疫国際教育研究センター

    • URL

      http://www.agri.tohoku.ac.jp/cfai/

    • Related Report
      2017 Annual Research Report
  • [Remarks] JSPS研究拠点形成事業先端拠点形成「食の安全性の飛躍的向上を目指した農免疫国際共同研究拠点形成」

    • URL

      http://www.agri.tohoku.ac.jp/fain/index.html

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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