Neuro-pathogenesis of flavivirus by hijack of dendritic transport
Project/Area Number |
16K15032
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Veterinary medical science
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Research Institution | Hokkaido University |
Principal Investigator |
YOSHII Kentaro 北海道大学, 獣医学研究院, 准教授 (50421988)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | フラビウイルス / 局所翻訳制御 / 脳高次機能 |
Outline of Final Research Achievements |
Flaviviruses represent a significant threat to public health worldwide, and several flaviviruses cause severe neurological disease in humans and animals. However, no specific treatment has been developed due to the lack of information about the detailed pathogenic mechanisms. In current study, we revealed that the transport of the viral RNA of tick-borne flavivirus in neuronal dendrites was involved in the development of the neurological disease. The virus hijacked the transport system of host mRNA in dendrites, which is important for neuronal functions, such as neurogenesis and the plasticity of the synaptic communication. Our findings of this unique virus-host interaction will promote the study of neurodegenerative diseases caused by disruption of dendritic mRNA transport and development of their treatment.
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Report
(3 results)
Research Products
(104 results)
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[Journal Article] Peroxiredoxins are important for the regulation of hydrogen peroxide concentrations in ticks and tick cell line2018
Author(s)
Kusakisako, K., Hernandez, E. P., Talactac, M. R., Yoshii, K., Umemiya-Shirafuji, R., Fujisaki, K. and Tanaka, T.
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Journal Title
Ticks Tick Borne Dis.
Volume: In press
Issue: 4
Pages: 870-881
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Characterization and antiviral activity of a newly identified defensin-like peptide, HEdefensin, in the hard tick Haemaphysalis longicornis2017
Author(s)
Talactac, M. R., Yada, Y., Yoshii, K., Hernandez, E. P., Kusakisako, K., Maeda, H., Galay, R. L., Fujisaki, K., Mochizuki, M. and Tanaka, T.
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Journal Title
Dev. Comp. Immunol.
Volume: 68
Pages: 98-107
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Synchronous Langat virus infection of Haemaphysalis longicornis using anal pore microinjection2017
Author(s)
Talactac, M. R., Yoshii, K., Hernandez, E. P., Kusakisako, K., Galay, R. L., Fujisaki, K., Mochizuki, M. and Tanaka, T.
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Journal Title
Viruses
Volume: 9(7)
Issue: 7
Pages: 189-189
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Escape of tick-borne flavivirus from 2’-C-methylated nucleoside antivirals is mediated by a single conservative mutation in NS5 that has a dramatic effect on viral fitness2017
Author(s)
Eyer L, Kondo H, Zouharov D, Hirano M, Valds J, Muto M, Kastl T, Kobayashi S, Haviernik J, Igarashi M, Kariwa H, Vaculovicova M, Cerny J, Kizek R, Krger A, Lienenklaus S, Dejmek M, Nencka R, Palus M, Salat J, Clercq ED, Yoshii K, Ruzek D
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Journal Title
J Virol
Volume: 91
Issue: 21
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Putative RNA viral sequences detected in an Ixodes scapularis-derived cell line.2016
Author(s)
Nakao R, Matsuno K, Qiu Y, Maruyama J, Eguchi N, Nao N, Kajihara M, Yoshii K, Sawa H, Takada A, Sugimoto C.
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Journal Title
Ticks Tick Borne Dis.
Volume: 8
Issue: 1
Pages: 103-111
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Novel antiviral activity of bromocriptine against dengue virus replication.2016
Author(s)
Kato F, Ishida Y, Oishi S, Fujii N, Watanabe S, Vasudevan SG, Tajima S, Takasaki T, Suzuki Y, Ichiyama K, Yamamoto N, Yoshii K, Takashima I, Kobayashi T, Miura T, Igarashi T, Hishiki T
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Journal Title
Antiviral Res.
Volume: 131
Pages: 141-147
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Characterization and antiviral activity of a newly identified defensin-like peptide, HEdefensin, in the hard tick Haemaphysalis longicornis2017
Author(s)
Melbourne Rio Talactac, Yurika Yada, Kentaro Yoshii, Emmanuel Pacia Hernandez, Kodai Kusakisako, Hiroki Maeda, Kozo Fujisaki, Masami Mochizuki, Tetsuya Tanaka
Organizer
第160回日本獣医学会学術集会
Related Report
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[Presentation] "Experimental transmission of tick-borne encephalitis virus surrogate Langat virus by Haemaphysalis longicornis"2016
Author(s)
Talactac, M. R., Yoshii, K., Hernandez, E. P., Kusakisako, K., Maeda, H., Fujisaki, K., Mochizuki, M., and Tanaka, T.
Organizer
第64回日本ウイルス学会学術集会
Place of Presentation
北海道札幌市札幌コンベンションセンター
Year and Date
2016-10-23
Related Report
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[Presentation] Development of a neutralization assay for multiple flaviviruses based on single-round infectious particles.2016
Author(s)
Matsuda, M., Yamanaka, A., Yoshii, K., Watashi, K., Aizaki, H., Konishi, E., Takasaki, T., Wakita, T., Suzuki, R.
Organizer
第64回日本ウイルス学会学術集会
Place of Presentation
北海道札幌市札幌コンベンションセンター
Year and Date
2016-10-23
Related Report
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[Presentation] Identification of host proteins interacting with the 3’ UTR of tick-borne encephalitis virus2016
Author(s)
Muto, M., Kamitani, W., Hirano, M., Kobayashi, S., Kariwa, H., Yoshii, K.
Organizer
第64回日本ウイルス学会学術集会
Place of Presentation
北海道札幌市札幌コンベンションセンター
Year and Date
2016-10-23
Related Report
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[Presentation] Investigation of the survival dynamics of Japan isolate Thogoto virus in Haemaphysalis longicornis2016
Author(s)
Talactac, M. R., Yoshii, K., Hernandez, E. P., Kusakisako, K., Maeda, H., Fujisaki, K., Mochizuki, M., and Tanaka, T.
Organizer
The 4th Sapporo Summer Seminar for One Health
Place of Presentation
北海道札幌市北海道大学大学院獣医学研究科
Year and Date
2016-09-20
Related Report
Int'l Joint Research
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[Presentation] Identification of host proteins interacting with the 3’ UTR of tick-borne encephalitis virus2016
Author(s)
Muto, M., Kamitani, W., Hirano, M., Kobayashi, S., Kariwa, H., Yoshii, K.
Organizer
The 4th Sapporo Summer Seminar for One Health
Place of Presentation
北海道札幌市北海道大学大学院獣医学研究科
Year and Date
2016-09-20
Related Report
Int'l Joint Research
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[Presentation] Survival dynamics of Japan isolate Thogoto virus (Hl-Kamigamo-25) in Haemaphysalis longicornis2016
Author(s)
Talactac, M. R., Yoshii, K., Hernandez, E. P., Kusakisako, K., Maeda, H., Fujisaki, K., Mochizuki, M., and Tanaka, T.
Organizer
第159回日本獣医学会学術集会
Place of Presentation
神奈川県藤沢市日本大学生物資源科学部
Year and Date
2016-09-06
Related Report
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[Presentation] Adaptation of Hantaan virus strain AA57 to Vero E6 cells affects the pathogenicity in mice2016
Author(s)
Kariwa, H., Maki, M., Seto, T., Kondo, H., Yoshimatsu, K., Arikawa, J., Yoshii, K.
Organizer
The X International Conference on HFRS, HPS & Hantaviruses
Place of Presentation
Colorado State University, Fort Collins, CO, USA.
Year and Date
2016-05-31
Related Report
Int'l Joint Research
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[Presentation] アジアにおけるLangat virusの感染状況の調査2016
Author(s)
下田宙, 早坂大輔, 好井健太朗, Boldbaatar Bazartseren, Worawut Rerkamnuaychoke, Thanmaporn Phichitrasilp, 本道栄一, Dung Van Nguyen, 米満研三, 鍬田龍星, 高野愛, 前田健
Organizer
第51回日本脳炎ウイルス生態学研究会
Place of Presentation
福島県耶麻郡猪苗代町ホテルリステル猪苗代
Year and Date
2016-05-13
Related Report
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