A novel strategy on inactivation of avian influenza virus by RNA editing system
| Project/Area Number |
16K15038
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Horimoto Taisuke 東京大学, 大学院農学生命科学研究科(農学部), 教授 (00222282)
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| Co-Investigator(Kenkyū-buntansha) |
村上 晋 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (10636757)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ウイルス |
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| Outline of Final Research Achievements |
In this study, we used a new RNA editing technology, CRISPR/FnCas9 system, for prevention of avian influenza virus infection, whose genome RNA would be inactivated. To this end, we constructed several influenza virus vectors, each of which expresses either rgRNA or FnCas9, by reverse genetics. However, we were not able to generate such vectors having proper inserted sequences, which could be utilized for this system.
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Report
(3 results)
Research Products
(3 results)
