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A novel strategy on inactivation of avian influenza virus by RNA editing system

Research Project

Project/Area Number 16K15038
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Research InstitutionThe University of Tokyo

Principal Investigator

Horimoto Taisuke  東京大学, 大学院農学生命科学研究科(農学部), 教授 (00222282)

Co-Investigator(Kenkyū-buntansha) 村上 晋  東京大学, 大学院農学生命科学研究科(農学部), 准教授 (10636757)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsウイルス
Outline of Final Research Achievements

In this study, we used a new RNA editing technology, CRISPR/FnCas9 system, for prevention of avian influenza virus infection, whose genome RNA would be inactivated. To this end, we constructed several influenza virus vectors, each of which expresses either rgRNA or FnCas9, by reverse genetics. However, we were not able to generate such vectors having proper inserted sequences, which could be utilized for this system.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2018 2017 2016

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Heparan sulfate proteoglycan is an important attachment factor for cell entry of Akabane and Schmallenberg viruses2017

    • Author(s)
      Murakami S, Takenaka-Uema A, Kobayashi T, Kato K, Shimojima M, Palmarini M, Horimoto T
    • Journal Title

      J Virol

      Volume: 91(15) Issue: 15

    • DOI

      10.1128/jvi.00503-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of an improved reverse genetics system for Akabane bunyavirus.2016

    • Author(s)
      Takenaka-Uema A, Horimoto T, et al.
    • Journal Title

      J. Virol. Methods

      Volume: 232 Pages: 16-20

    • DOI

      10.1016/j.jviromet.2015.12.014

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] PB1-K577E mutation in H9N2 avian influenza virus increases polymerase activity and pathogenicity for mice2018

    • Author(s)
      Kamiki H, Matsugo H, Kobayashi T, Murakami S, Horimoto T
    • Organizer
      第9回東アジア獣医ジョイントシンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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