| Project/Area Number |
16K15044
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
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| Research Collaborator |
Maezawa Masaki
Watanabe Ken-ichi
Horiuchi Noriyuki
Kobayashi Yoshiyasu
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 牛白血病 / 若齢発症 / エピジェネティクス / 牛白血病ウイルス / 地方病性牛白血病、 / 若齢発症、 / メチル化解析 / 症例報告 / 地方病性牛白血病 / 獣医学 / 遺伝子 / 癌 |
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| Outline of Final Research Achievements |
The frequency of methylation of promoter region of the apoptosis related gene BMP-6 in enzootic bovine leukosis (EBL) cases of young fattening cattle less than 3 years was found to be higher compared to EBL cases more than 3 years old. In the early onset of EBL in young fattening cows, environmental factors such as feeding management specific to fattening cows were considered to be involved by affecting epigenetics change to the animal genome. Furthermore, bovine leukemia virus (BLV) was frequently integrated into the promoter regions and transcriptionally active regions of host genome in young EBL less than 3 years old. This finding also suggested that BLV integration sites are involved in the early onset of EBL.
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| Academic Significance and Societal Importance of the Research Achievements |
若齢肥育牛の成牛型牛白血病発症に発がん関連遺伝子であるBMP-6のエピジェネティックな変化が明らかにされたことにより、飼養管理、とくに栄養学的観点からウイルス発がんを制御する手掛かりを見出すことが期待される。また、研究成果は畜産・獣医学において牛白血病の発症予防に資するだけではなく、医学領域における成人T細胞型白血病の動物モデルとして、発症メカニズムの解明および発症予防に貢献できる可能性が高い。
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